ArticleMechanisms of development
Lola regulates cell fate by antagonizing Notch induction in the Drosophila eye.
Article in Mechanisms of development. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 31 citations in OpenAlex.
- Genome-Wide Association Study and transcriptome analysis reveals a complex gene network that regulates opsin gene expression and cell fate determination inbioRxiv : the preprint server for biology · 2024Article
- Analysis of the chromatin landscape and RNA polymerase II binding at SIN3-regulated genes.Biology open · 2023Article
- A single cell genomics atlas of the Drosophila larval eye reveals distinct photoreceptor developmental timelines.Nature communications · 2023Article
- Lola-I is a promoter pioneer factor that establishes de novo Pol II pausing during development.Nature communications · 2023Article
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- Poly(ADP-ribose) polymerase 1 in genome-wide expression control in Drosophila.Scientific reports · 2020Article
- A cell atlas of the adultProceedings of the National Academy of Sciences of the United States of America · 2020Article
- Lola regulateseLife · 2020Article
- Modulation of miR-210 alters phasing of circadian locomotor activity and impairs projections of PDF clock neurons in Drosophila melanogaster.PLoS genetics · 2018Article
- Antagonistic PCP Signaling Pathways in the developing Drosophila eye.Scientific reports · 2018Article
- Dedifferentiation of neurons precedes tumor formation in Lola mutants.Developmental cell · 2014Article
- Dendrite architecture organized by transcriptional control of the F-actin nucleator Spire.Development (Cambridge, England) · 2014Article
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- A genome-wide analysis reveals that the Drosophila transcription factor Lola promotes axon growth in part by suppressing expression of the actin nucleation factor Spire.Neural development · 2011Article
- Genome-wide analysis of self-renewal in Drosophila neural stem cells by transgenic RNAi.Cell stem cell · 2011Article
- Prospero and Pax2 combinatorially control neural cell fate decisions by modulating Ras- and Notch-dependent signaling.Neural development · 2011Article
- Genome-wide identification of cis-regulatory motifs and modules underlying gene coregulation using statistics and phylogeny.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
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2 authors at 1 institution in 1 country.
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Abstract
Lola is a transcription repressor that regulates axon guidance in the developing embryonic nervous system of Drosophila. Here, we show that Lola regulates two binary cell fate decisions guided by Notch inductive signaling in the developing eye: the R3-R4 and the R7-cone cell fate choices. Lola is required cell-autonomously in R3 for its specification, and Lola transforms R4 into R3 if overexpressed. Lola also promotes R7 fate at the expense of cone cell fate. Lola antagonizes Notch-dependent gene expression and Notch-dependent fate transformation. Expression analysis shows that Lola is constitutively present in all photoreceptors and cone cells. We propose that when a precursor cell receives a weak Notch inductive signal, it is not sufficiently strong to overcome the constitutive repression of target gene transcription by Lola. A precursor that receives a strong Notch inductive signal expresses target genes despite a constitutive repression by Lola. The predicted consequence of this mechanism is to sharpen a cell's responsiveness to Notch signaling by creating a threshold.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.