ArticleJournal of translational medicine2007
Mononuclear cells modulate the activity of pancreatic stellate cells which in turn promote fibrosis and inflammation in chronic pancreatitis.
Article in Journal of translational medicine, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 43 citations in OpenAlex.
- Mechanistic insights into pancreatic duct pressure: from basic physiology to translational implications.Current opinion in gastroenterology · 2026Review
- Therapeutic potential of traditional Chinese medicine in pancreatic fibrosis: mechanisms of TCM formulas and active ingredients.Frontiers in pharmacology · 2025Review
- Pancreatic stellate cells: Key players in pancreatic health and diseases (Review).Molecular medicine reports · 2024Review
- Vitamin A-coupled liposomes carrying TLR4-silencing shRNA induce apoptosis of pancreatic stellate cells and resolution of pancreatic fibrosis.Journal of molecular medicine (Berlin, Germany) · 2018Article
- Dachaihu decoction ameliorates pancreatic fibrosis by inhibiting macrophage infiltration in chronic pancreatitis.World journal of gastroenterology · 2017Article
- Inhibition of Jak/STAT signaling reduces the activation of pancreatic stellate cells in vitro and limits caerulein-induced chronic pancreatitis in vivo.Scientific reports · 2017Article
- Complement Component 5 Mediates Development of Fibrosis, via Activation of Stellate Cells, in 2 Mouse Models of Chronic Pancreatitis.Gastroenterology · 2015Article
- High glucose aggravates the detrimental effects of pancreatic stellate cells on Beta-cell function.International journal of endocrinology · 2014Article
- Article
- The impact of MFG-E8 in chronic pancreatitis: potential for future immunotherapy?BMC gastroenterology · 2013Article
- Senescence determines the fate of activated rat pancreatic stellate cells.Journal of cellular and molecular medicine · 2012Article
- The role of stroma in pancreatic cancer: diagnostic and therapeutic implications.Nature reviews. Gastroenterology & hepatology · 2012Review
- Pancreatic stellate cells: a starring role in normal and diseased pancreas.Frontiers in physiology · 2012Article
- Article
- Role of Plasma MMP 9 levels in the Pathogenesis of Chronic Pancreatitis.Indian journal of clinical biochemistry : IJCB · 2011Article
- Organ-, inflammation- and cancer specific transcriptional fingerprints of pancreatic and hepatic stellate cells.Molecular cancer · 2010Article
- Molecular basis for pancreatitis.Current opinion in gastroenterology · 2008Review
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInteractions between mononuclear cells and activated pancreatic myofibroblasts (pancreatic stellate cells; PSC) may contribute to inflammation and fibrosis in chronic pancreatitis (CP).
methodsMarkers of fibrosis and inflammation were concomitantly analysed by immunohistochemistry in chronic pancreatitis tissues. In vitro, PSC were stimulated with TNFalpha and LPS. Primary human blood mononuclear cells (PBMC) and PSC were cocultured, followed by analysis of cytokines and extracellular matrix (ECM) proteins. PBMC were derived from healthy donors and CP and septic shock patients.
resultsIn areas of mononuclear cell infiltration in chronic pancreatitis tissues, there was decreased immunoreactivity for collagen1 and fibronectin, in contrast to areas with sparse mononuclear cells, although PSC were detectable in both areas. LPS and TNFalpha induced collagen1 and fibronectin levels as well as the matrix degradation enzyme MMP-1. Coculture experiments with PSC and PBMC revealed increased fibronectin secretion induced by PBMC. In addition, donor and CP PBMC significantly induced an increase in IL-6, MCP-1 and TGFbeta levels under coculture conditions. Determination of the source of cytokines and ECM proteins by mRNA expression analysis confirmed PSC as major contributors of ECM production. The increase in cytokine expression was PBMC- and also PSC-derived.
conclusionMononuclear cells modulate the activity of pancreatic stellate cells, which may in turn promote fibrosis and inflammation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.