ArticleMalaria journal2007
How is childhood development of immunity to Plasmodium falciparum enhanced by certain antimalarial interventions?
Article in Malaria journal, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 42 citations in OpenAlex.
- Trial
- Antibody and T-cell responses associated with experimental human malaria infection or vaccination show limited relationships.Immunology · 2015Trial
- RTS,S vaccination is associated with serologic evidence of decreased exposure to Plasmodium falciparum liver- and blood-stage parasites.Molecular & cellular proteomics : MCP · 2015Trial
- Trial
- Impact of intermittent preventive treatment with sulfadoxine-pyrimethamine on antibody responses to erythrocytic-stage Plasmodium falciparum antigens in infants in Mozambique.Clinical and vaccine immunology : CVI · 2008Trial
- Duration of protection against malaria and anaemia provided by intermittent preventive treatment in infants in Navrongo, Ghana.PloS one · 2008Trial
- Sterile protection against relapsing malaria with a single-shot vaccine.NPJ vaccines · 2022Article
- Analysis of Preventive Interventions for Malaria: Exploring Partial and Complete Protection and Total and Primary Intervention Effects.American journal of epidemiology · 2015Article
- Article
- Plasmodium attenuation: connecting the dots between early immune responses and malaria disease severity.Frontiers in microbiology · 2014Article
- Analysis of partial and complete protection in malaria cohort studies.Malaria journal · 2013Article
- Infection and treatment immunizations for successful parasite vaccines.Trends in parasitology · 2013Article
- Immune mechanisms in malaria: new insights in vaccine development.Nature medicine · 2013Review
- Rational deployment of antimalarial drugs in Africa: should first-line combination drugs be reserved for paediatric malaria cases?Parasitology · 2011Article
- Induction of antimalaria immunity by pyrimethamine prophylaxis during exposure to sporozoites is curtailed by parasite resistance.Antimicrobial agents and chemotherapy · 2011Article
- Impact of the RTS,S malaria vaccine candidate on naturally acquired antibody responses to multiple asexual blood stage antigens.PloS one · 2011Article
- Mode of action and choice of antimalarial drugs for intermittent preventive treatment in infants.Transactions of the Royal Society of Tropical Medicine and Hygiene · 2009Article
- Genetic diversity and malaria vaccine design, testing and efficacy: preventing and overcoming 'vaccine resistant malaria'.Parasite immunology · 2009Review
- Novel pfdhps haplotypes among imported cases of Plasmodium falciparum malaria in the United Kingdom.Antimicrobial agents and chemotherapy · 2009Article
- Low density parasitaemia, red blood cell polymorphisms and Plasmodium falciparum specific immune responses in a low endemic area in northern Tanzania.BMC infectious diseases · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The development of acquired protective immunity to Plasmodium falciparum infection in young African children is considered in the context of three current strategies for malaria prevention: insecticide-impregnated bed nets or curtains, anti-sporozoite vaccines and intermittent preventive therapy. Evidence is presented that each of these measures may permit attenuated P. falciparum blood-stage infections, which do not cause clinical malaria but can act as an effective blood-stage "vaccine". It is proposed that the extended serum half-life, and rarely considered liver-stage prophylaxis provided by the anti-folate combination sulphadoxine-pyrimethamine frequently lead to such attenuated infections in high transmission areas, and thus contribute to the sustained protection from malaria observed among children receiving the combination as intermittent preventative therapy or for parasite clearance in vaccine trials.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.