ArticleBMC medical genetics2007
Impact of estrogen receptor gene polymorphisms and mRNA levels on obesity and lipolysis--a cohort study.
Article in BMC medical genetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 44 citations in OpenAlex.
- Association of estrogen receptor 2 gene polymorphisms with obesity in women (obesity and estrogen receptor 2 gene).Maturitas · 2009Trial
- Therapeutic nutrition strategies for the shared pathophysiology of obesity and sleep-disordered breathings.Nutrition journal · 2025Review
- The evolutionary impact and influence of oestrogens on adipose tissue structure and function.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Review
- Article
- The Regulation of Adipose Tissue Health by Estrogens.Frontiers in endocrinology · 2022Review
- An exploratory analysis on the influence of genetic variants on weight gain among etonogestrel contraceptive implant users.Contraception · 2020Article
- Effects of ERβ and ERα on OVX-induced changes in adiposity and insulin resistance.The Journal of endocrinology · 2020Article
- Ethnic differences in regional adipose tissue oestrogen receptor gene expression.Endocrine connections · 2019Article
- Identification of transcription factors potentially involved in human adipogenesis in vitro.Molecular genetics & genomic medicine · 2017Article
- Di-(2-Ethylhexyl)-Phthalate (DEHP) Causes Impaired Adipocyte Function and Alters Serum Metabolites.PloS one · 2015Article
- Significance of rs1271572 in the estrogen receptor beta gene promoter and its correlation with breast cancer in a southwestern Chinese population.Journal of biomedical science · 2013Article
- Hormonal parameters and sex hormone receptor gene polymorphisms in men with autoimmune diseases.Rheumatology international · 2013Article
- Sex differences in human adipose tissues - the biology of pear shape.Biology of sex differences · 2012Article
- Homocysteine suppresses lipolysis in adipocytes by activating the AMPK pathway.American journal of physiology. Endocrinology and metabolism · 2011Article
- Estrogen receptor alpha polymorphisms and the risk of malignancies.Pathology oncology research : POR · 2010Article
- Influence of age and obesity on serum estradiol, estrone, and sex hormone binding globulin concentrations following oral estrogen administration in postmenopausal women.The Journal of clinical endocrinology and metabolism · 2009Article
- Variants of ESR1, APOE, LPL and IL-6 loci in young healthy subjects: association with lipid status and obesity.BMC research notes · 2009Article
- Effects of two common polymorphisms in the 3' untranslated regions of estrogen receptor beta on mRNA stability and translatability.BMC genetics · 2009Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe estrogen receptors alpha and beta (ESR1, ESR2) have been implicated in adiposity, lipid metabolism and feeding behaviour. In this report we analyse ESR1 and ESR2 gene single nucleotide polymorphisms (SNPs) for association with obesity. We also relate adipose tissue ESR1 mRNA levels and ESR1 SNPs to adipocyte lipolysis and lipogenesis phenotypes.
methods23 ESR1 and 11 ESR2 tag-SNPs, covering most of the common haplotype variation in each gene according to HAPMAP data, were analysed by Chi2 for association with obesity in a cohort comprising 705 adults with severe obesity and 402 lean individuals. Results were replicated in a cohort comprising 837 obese and 613 lean subjects. About 80% of both cohorts comprised women and 20% men. Adipose tissue ESR1 mRNA was quantified in 122 women and related to lipolysis and lipogenesis by multiple regression. ESR1 SNPs were analysed for association with adipocyte lipolysis and lipogenesis phenotypes in 204 obese women by simple regression.
resultsNo ESR1 SNP was associated with obesity. Five ESR2 SNPs displayed nominal significant allelic association with obesity in women and one in men. The two ESR2 SNPs associated with obesity with nominal P value < 0.01 were genotyped in a second cohort where no association with obesity was observed. There was an inverse correlation between ESR1 mRNA levels in abdominal subcutaneous (sc) adipose tissue and basal lipolysis, as well as responsiveness to adrenoceptor agonists independent of age and BMI (P value 0.009-0.045). ESR1 rs532010 was associated with lipolytic sensitivity to noradrenaline (nominal P value 0.012), and ESR1 rs1884051 with responsiveness to the non-selective beta-adrenoceptor agonist isoprenaline (nominal P value 0.05). These associations became non-significant after Bonferroni correction.
conclusionESR1 gene alleles are unlikely to be a major cause of obesity in women. A minor importance of ESR2 on severe obesity cannot be excluded. The inverse correlation between ESR1 mRNA levels and lipolytic responsiveness to adrenoceptor agonists implies that low adipose tissue ESR1 levels attenuate catecholamine resistance in sc fat cells of obese women hereby contributing to loss of sc and gain of visceral fat. There is no evidence for a genetic impact of ESR1 on lipolysis or lipogenesis.
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