ArticleBMC evolutionary biology2007
An insight into the phylogenetic history of HOX linked gene families in vertebrates.
Article in BMC evolutionary biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 33 citations in OpenAlex.
- PAHG: the database of human multi-gene families.BMC genomic data · 2025Article
- Evolution through segmental duplications and losses: a Super-Reconciliation approach.Algorithms for molecular biology : AMB · 2020Article
- Evolutionary history of the human multigene families reveals widespread gene duplications throughout the history of animals.BMC evolutionary biology · 2019Article
- Phylogenetic analyses of human 1/2/8/20 paralogons suggest segmental duplications during animal evolution.3 Biotech · 2019Article
- Hox genes and evolution.F1000Research · 2016Review
- Diversification of four human HOX gene clusters by step-wise evolution rather than ancient whole-genome duplications.Development genes and evolution · 2015Review
- Human intronic enhancers control distinct sub-domains of Gli3 expression during mouse CNS and limb development.BMC developmental biology · 2010Article
- A clustered set of three Sp-family genes is ancestral in the Metazoa: evidence from sequence analysis, protein domain structure, developmental expression patterns and chromosomal location.BMC evolutionary biology · 2010Article
- Phylogenomic analyses reveal the evolutionary origin of the inhibin alpha-subunit, a unique TGFbeta superfamily antagonist.PloS one · 2010Article
- Piecemeal or big bangs: correlating the vertebrate evolution with proposed models of gene expansion events.Nature reviews. Genetics · 2010Article
- Evolution and functional diversification of the GLI family of transcription factors in vertebrates.Evolutionary bioinformatics online · 2009Article
- A census of human transcription factors: function, expression and evolution.Nature reviews. Genetics · 2009Review
- Are we degenerate tetraploids? More genomes, new facts.Biology direct · 2008Article
- Phylogenetic and chromosomal analyses of multiple gene families syntenic with vertebrate Hox clusters.BMC evolutionary biology · 2008Article
- Early vertebrate chromosome duplications and the evolution of the neuropeptide Y receptor gene regions.BMC evolutionary biology · 2008Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe human chromosomes 2q, 7, 12q and 17q show extensive intra-genomic homology, containing duplicate, triplicate and quadruplicate paralogous regions centered on the HOX gene clusters. The fact that two or more representatives of different gene families are linked with HOX clusters is taken as evidence that these paralogous gene sets might have arisen from a single chromosomal segment through block or whole chromosome duplication events. This would imply that the constituent genes including the HOX clusters reflect the architecture of a single ancestral block (before vertebrate origin) where all of these genes were linked in a single copy.
resultsIn the present study we have employed the currently available set of protein data for a wide variety of vertebrate and invertebrate genomes to analyze the phylogenetic history of 11 multigene families with three or more of their representatives linked to human HOX clusters. A topology comparison approach revealed four discrete co-duplicated groups: group 1 involves the genes from GLI, HH, INHB, IGFBP (cluster-1), and SLC4A families; group 2 involves ERBB, ZNFN1A, and IGFBP (cluster-2) gene families; group 3 involves the HOX clusters and the SP gene family; group 4 involves the integrin beta chain and myosine light chain families. The distinct genes within each co-duplicated group share the same evolutionary history and are duplicated in concert with each other, while the constituent genes of two different co-duplicated groups may not share their evolutionary history and may not have duplicated simultaneously.
conclusionWe conclude that co-duplicated groups may themselves be remnants of ancient small-scale duplications (involving chromosomal segments or gene-clusters) which occurred at different time points during chordate evolution. Whereas the recent combination of genes from distinct co-duplicated groups on different chromosomal regions (human chromosomes 2q, 7, 12q, and 17q) is probably the outcome of subsequent rearrangement of genomic segments, including syntenic groups of genes.
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