ArticleImmunogenetics2007
Trans-species polymorphism and evidence of selection on class II MHC loci in tuco-tucos (Rodentia: Ctenomyidae).
Article in Immunogenetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 57 citations in OpenAlex.
- Increased heterozygosity and balancing selection in isofemale generations of Anopheles stephensi under laboratory conditions.BMC genomics · 2025Article
- Adaptive evolution of major histocompatibility complex class I immune genes and disease associations in coastal juvenile sea turtles.Royal Society open science · 2022Article
- Trans-specific polymorphism and the convergent evolution of supertypes in major histocompatibility complex class II genes in darters (Ecology and evolution · 2022Article
- Distinct evolutionary trajectories of MHC class I and class II genes in Old World finches and buntings.Heredity · 2021Article
- Spatiotemporal adaptive evolution of an MHC immune gene in a frog-fungus disease system.Heredity · 2021Article
- Major histocompatibility complex class II DR and DQ evolution and variation in wild capuchin monkey species (Cebinae).PloS one · 2021Article
- Genetic variation and selection in the major histocompatibility complex Class II gene in the Guizhou pony.PeerJ · 2020Article
- Extensive shared polymorphism at non-MHC immune genes in recently diverged North American prairie grouse.Immunogenetics · 2018Article
- Genetic variation of major histocompatibility complex genes in the endangered red-crowned crane.Immunogenetics · 2017Article
- A genome-wide scan for genes under balancing selection in Drosophila melanogaster.BMC evolutionary biology · 2017Article
- Contrasting patterns of selection between MHC I and II across populations of Humboldt and Magellanic penguins.Ecology and evolution · 2016Article
- Contrasting evolutionary histories of MHC class I and class II loci in grouse--effects of selection and gene conversion.Heredity · 2016Article
- Genetic Variation at Exon 2 of the MHC Class II DQB Locus in Blue Whale (Balaenoptera musculus) from the Gulf of California.PloS one · 2016Article
- Genetic diversity comparison of the DQA gene in European rabbit (Oryctolagus cuniculus) populations.Immunogenetics · 2015Article
- Disparate independent genetic events disrupt the secondary metabolism gene perA in certain symbiotic Epichloë species.Applied and environmental microbiology · 2015Article
- Nucleotide variability at its limit? Insights into the number and evolutionary dynamics of the sex-determining specificities of the honey bee Apis mellifera.Molecular biology and evolution · 2014Article
- Diversity and selection of MHC class IIb gene exon3 in Chinese alligator.Molecular biology reports · 2013Article
- Evolution of the MHC-DQB exon 2 in marine and terrestrial mammals.Immunogenetics · 2013Article
- Evidence for evolutionary convergence at MHC in two broadly distributed mesocarnivores.Immunogenetics · 2012Article
- Adaptive molecular evolution of the Major Histocompatibility Complex genes, DRA and DQA, in the genus Equus.BMC evolutionary biology · 2011Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Balancing selection acting over the evolutionary history of a lineage can result in the retention of alleles among species for longer than expected under neutral evolution. The associated pattern of trans-species polymorphism, in which similar or even identical alleles are shared among species, is often used to infer that balancing selection has occurred. The genes of the major histocompatibility complex (MHC) are thought to be subject to balancing selection that maintains alleles associated with response to specific pathogens. To explore the role of balancing selection in shaping MHC diversity in ctenomyid rodents, we examined allelic variability at the class II DRB and DQA loci in 18 species in the genus Ctenomys. Previous studies of four of these species had revealed significant within-population evidence of positive selection on MHC loci. The current study expands upon these analyses to (1) evaluate among-species evidence of positive selection and (2) explore the potential for balancing selection on MHC genes. Interspecific nucleotide sequence variation revealed significant evidence of positive selection on the DRB and DQA loci. At the same time, comparisons of phylogenetic trees for these MHC loci with a putative species tree based on mitochondrial sequence data revealed multiple examples of trans-specific polymorphism, including sharing of identical DRB and DQA alleles among distantly related species of Ctenomys. These findings suggest that MHC genes in these animals have historically been subject to balancing selection and yield new insights into the complex suite of forces shaping MHC diversity in free-living vertebrates.
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