Evidence map›Paper›PMID 18049717›Full record

ArticleCellscience2006

Potential Role of the AMP-activated Protein Kinase in Regulation of Insulin Action.

Jonathan S Fisher

Open access · greenAbstract read
In one paragraph

Article in Cellscience, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.4field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 29 citations in OpenAlex.

  1. Prospects of potential adipokines as therapeutic agents in obesity-linked atherogenic dyslipidemia and insulin resistance.The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2023
    Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Glycosides fromOxidative medicine and cellular longevity · 2017
    Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. A role for AMPK in increased insulin action after serum starvation.American journal of physiology. Cell physiology · 2010
    Article
  12. Antidiabetic drug metformin (GlucophageR) increases biogenesis of Alzheimer's amyloid peptides via up-regulating BACE1 transcription.Proceedings of the National Academy of Sciences of the United States of America · 2009 · on this map
    Article
  13. Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Jonathan S FisherDepartment of Biology, 3507 Laclede Ave., Saint Louis University St. Louis, MO 63103 USA.
Saint Louis University · US

Funding

ARK5 AMP-activated protein kinase and glucose transportK01DK066330 · NIDDK · SAINT LOUIS UNIVERSITY · PI FISHER, JONATHAN S · 2004 to 2007
$373k
NIDDK NIH HHS K01 DK066330
6 · The paper itself

Abstract

Because of the predominant role of skeletal muscle in insulin-stimulated clearance of blood glucose, understanding mechanisms for increasing the ability of muscle to respond to insulin could potentially lead to novel strategies for treatment or prevention of diabetes. Recently, the AMP activated protein kinase (AMPK) has emerged as a promising candidate for potentiation of insulin action. Several antidiabetic drugs have been shown to activate AMPK, cellular stresses such as exercise that increase AMPK activity also increase insulin action, and several downstream targets of AMPK seem to be involved in regulation of insulin action. Although the picture is currently incomplete, it seems possible that AMPK or one of its effectors is a positive regulator of insulin-stimulated glucose transport. In addition to discussion of the latest literature regarding AMPK and insulin action, this review includes a non-technical summary for students, academics from other fields, interested professionals, and the general public.

Identifiers

PMID18049717
PMCPMC2099311
OpenAlexW1522904259

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.