ArticleNucleic acids research2008
Interplay of ion binding and attraction in DNA condensed by multivalent cations.
Article in Nucleic acids research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
43 citing papers in PubMed, 105 citations in OpenAlex.
- Chromatin Packing Domain Engineering Through the Manipulation of Nuclear Cationic States.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Multivalent cations stabilize DNA duplexes beyond charge neutralization.Chemical science · 2026Article
- Translational Entropy-Driven Competitive and Additive Effects on DNA Higher-Order Structure via Ion Exchange Between Cations of Different Valencies.Entropy (Basel, Switzerland) · 2026Review
- Local cation-clamping distorts and softens RNA duplex.Communications biology · 2026Article
- Article
- Effective interactions and phase behavior of protein solutions in the presence of hexamine cobalt(III) chloride.The European physical journal. E, Soft matter · 2023Article
- New Insights into the Phototoxicity of Anthracene-Based Chromophores: The Chloride Salt Effect†.Chemical research in toxicology · 2023Article
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- Unravelling How Single-Stranded DNA Binding Protein Coordinates DNA Metabolism Using Single-Molecule Approaches.International journal of molecular sciences · 2023Review
- Ion-Induced Volume Transition in Gels and Its Role in Biology.Gels (Basel, Switzerland) · 2021Review
- Virus Isoelectric Point Estimation: Theories and Methods.Applied and environmental microbiology · 2021Review
- Improved Virus Isoelectric Point Estimation by Exclusion of Known and Predicted Genome-Binding Regions.Applied and environmental microbiology · 2020Article
- Structure-guided DNA-DNA attraction mediated by divalent cations.Nucleic acids research · 2020Article
- The promotion and suppression of DNA charge neutralization by the cosolute ectoine.RSC advances · 2019Article
- New Aspects of Magnesium Function: A Key Regulator in Nucleosome Self-Assembly, Chromatin Folding and Phase Separation.International journal of molecular sciences · 2019Review
- DNA Compaction and Charge Neutralization Regulated by Divalent Ions in very Low pH Solution.Polymers · 2019Article
- The Mixing Counterion Effect on DNA Compaction and Charge Neutralization at Low Ionic Strength.Polymers · 2018Article
- Role of Disulfide Bonds on DNA Packaging Forces in Bull Sperm Chromatin.Biophysical journal · 2017Article
- Divalent Ion-Mediated DNA-DNA Interactions: A Comparative Study of Triplex and Duplex.Biophysical journal · 2017Article
- Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 3 countries.
Funding
Abstract
We have measured forces generated by multivalent cation-induced DNA condensation using single-molecule magnetic tweezers. In the presence of cobalt hexammine, spermidine, or spermine, stretched DNA exhibits an abrupt configurational change from extended to condensed. This occurs at a well-defined condensation force that is nearly equal to the condensation free energy per unit length. The multivalent cation concentration dependence for this condensation force gives the apparent number of multivalent cations that bind DNA upon condensation. The measurements show that the lower critical concentration for cobalt hexammine as compared to spermidine is due to a difference in ion binding, not a difference in the electrostatic energy of the condensed state as previously thought. We also show that the resolubilization of condensed DNA can be described using a traditional Manning-Oosawa cation adsorption model, provided that cation-anion pairing at high electrolyte concentrations is taken into account. Neither overcharging nor significant alterations in the condensed state are required to describe the resolubilization of condensed DNA. The same model also describes the spermidine3+/Na+ phase diagram measured previously.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.