ArticleBMC bioinformatics2007
Framework for a protein ontology.
Article in BMC bioinformatics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.
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Who cites it
44 citing papers in PubMed, 1 synthesis or guideline pooled it, 106 citations in OpenAlex.
- The Progenetix oncogenomic resource in 2021.Database : the journal of biological databases and curation · 2021Pooled it
- The protein-protein interaction ontology: for better representing and capturing the biological context of protein interaction.BMC genomics · 2021Article
- CEDAR OnDemand: a browser extension to generate ontology-based scientific metadata.BMC bioinformatics · 2018Article
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- A method for increasing expressivity of Gene Ontology annotations using a compositional approach.BMC bioinformatics · 2014Article
- Managing, analysing, and integrating big data in medical bioinformatics: open problems and future perspectives.BioMed research international · 2014Review
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- Semantic integration of gene expression analysis tools and data sources using software connectors.BMC genomics · 2013Article
- The Vertebrate Trait Ontology: a controlled vocabulary for the annotation of trait data across species.Journal of biomedical semantics · 2013Article
- Epilepsy informatics and an ontology-driven infrastructure for large database research and patient care in epilepsy.Epilepsia · 2013Review
- Toward semantic modeling of pharmacogenomic knowledge for clinical and translational decision support.AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science · 2013Article
- Ontologies as integrative tools for plant science.American journal of botany · 2012Article
- Ontological labels for automated location of anatomical shape differences.Journal of biomedical informatics · 2012Article
- Bioinformatics advances in saliva diagnostics.International journal of oral science · 2012Review
- Improving integrative searching of systems chemical biology data using semantic annotation.Journal of cheminformatics · 2012Article
- Uberon, an integrative multi-species anatomy ontology.Genome biology · 2012Article
- Multiscale integration of -omic, imaging, and clinical data in biomedical informatics.IEEE reviews in biomedical engineering · 2012Review
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- A UML profile for the OBO relation ontology.BMC genomics · 2012Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
Biomedical ontologies are emerging as critical tools in genomic and proteomic research, where complex data in disparate resources need to be integrated. A number of ontologies describe properties that can be attributed to proteins. For example, protein functions are described by the Gene Ontology (GO) and human diseases by SNOMED CT or ICD10. There is, however, a gap in the current set of ontologies - one that describes the protein entities themselves and their relationships. We have designed the PRotein Ontology (PRO) to facilitate protein annotation and to guide new experiments. The components of PRO extend from the classification of proteins on the basis of evolutionary relationships to the representation of the multiple protein forms of a gene (products generated by genetic variation, alternative splicing, proteolytic cleavage, and other post-translational modifications). PRO will allow the specification of relationships between PRO, GO and other ontologies in the OBO Foundry. Here we describe the initial development of PRO, illustrated using human and mouse proteins involved in the transforming growth factor-beta and bone morphogenetic protein signaling pathways.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.