Evidence map›Paper›PMID 18047692›Full record

ReviewGenome biology2007

Transposons for cancer gene discovery: Sleeping Beauty and beyond.

Lara S Collier, David A Largaespada

Open access · bronzeAbstract readReview
In one paragraph

Review in Genome biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 26 citations in OpenAlex.

  1. Journal for immunotherapy of cancer · 2026
    Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Transposon transgenesis in Xenopus.Methods (San Diego, Calif.) · 2010
    Review
  16. Cancer gene discovery in mouse and man.Biochimica et biophysica acta · 2009
    Review
  17. Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Lara S CollierThe Department of Genetics, Cell Biology and Development, The Cancer Center, The University of Minnesota Twin Cities, Church St SE, Minneapolis, Minnesota 55455, USA. lsc5e@alumni.virginia.edu
David A Largaespada
University of Minnesota · US

Funding

Sleeping Beauty for uncovering cancer genes in miceR01CA113636 · NCI · UNIVERSITY OF MINNESOTA · PI LARGAESPADA, DAVID ANDREW · 2006 to 2016
$2.5M
Sleeping Beauty for cancer gene discoveryK01CA122183 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI COLLIER, LARA S · 2006 to 2010
$729k
Transposon-based somatic mutagenesis/prostate cancer geneticsR21CA118600 · NCI · UNIVERSITY OF MINNESOTA · PI LARGAESPADA, DAVID ANDREW · 2006 to 2007
$385k
NCI NIH HHS K01 CA122183NCI NIH HHS K01CA122183NCI NIH HHS R01 CA113636NCI NIH HHS R01CA113636NCI NIH HHS R21 CA118600NCI NIH HHS R21CA118600
6 · The paper itself

Abstract

The use of Sleeping Beauty transposons as somatic mutagens to discover cancer genes in hematopoietic tumors and sarcomas has been documented. Here, we discuss the future of Sleeping Beauty for cancer genetic studies and the potential use of additional transposable elements for somatic mutagenesis.

Indexed as

Genes, NeoplasmAnimalsDNA Transposable ElementsGene RearrangementHumansMutagenesisTransgenesTransposasesDNA Transposable ElementsTransposases

Identifiers

PMID18047692
PMCPMC2106843
OpenAlexW2159940473

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.