ArticleNeural computation2008
A-type K(+) current can act as a trigger for bursting in the absence of a slow variable.
Article in Neural computation, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Synaptic and intrinsic membrane defects disrupt early neural network dynamics in Down syndrome.Nature communications · 2026Article
- Sex differences in pituitary corticotroph excitability.Frontiers in physiology · 2023Article
- Emergence of Mixed Mode Oscillations in Random Networks of Diverse Excitable Neurons: The Role of Neighbors and Electrical Coupling.Frontiers in computational neuroscience · 2020Article
- A computational model for gonadotropin releasing cells in the teleost fish medaka.PLoS computational biology · 2019Article
- Article
- CA1 pyramidal cells have diverse biophysical properties, affected by development, experience, and aging.PeerJ · 2017Article
- From global to local: exploring the relationship between parameters and behaviors in models of electrical excitability.Journal of computational neuroscience · 2016Article
- Models of electrical activity: calibration and prediction testing on the same cell.Biophysical journal · 2012Article
- CROSS-CURRENTS BETWEEN BIOLOGY AND MATHEMATICS: THE CODIMENSION OF PSEUDO-PLATEAU BURSTING.Discrete and continuous dynamical systems. Series A · 2012Article
- Mixed mode oscillations as a mechanism for pseudo-plateau bursting.Journal of computational neuroscience · 2010Article
- Predicting the activity phase of a follower neuron with A-current in an inhibitory network.Biological cybernetics · 2008Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Models of bursting in single cells typically include two subsystems with different timescales. Variations in one or more slow variables switch the system between a silent and a spiking state. We have developed a model for bursting in the pituitary lactotroph that does not include any slow variable. The model incorporates fast, noninactivating calcium and potassium currents (the spike-generating mechanism), as well as the fast, inactivating A-type potassium current (I(A)). I(A) is active only briefly at the beginning of a burst, but this brief impulse of I(A) acts as a burst trigger, injecting the spike trajectory close to an unstable steady state. The spiraling of the trajectory away from the steady state produces a period of low-amplitude spiking typical of lactotrophs. Increasing the conductance of A-type potassium current brings the trajectory closer to the unstable steady state, increasing burst duration. However, this also increases interburst interval, and for larger conductance values, all activity stops. To our knowledge, this is the first example of a physiologically based, single-compartmental model of bursting with no slow subsystem.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.