ArticleJournal of molecular evolution2008
The lengthening of a giant protein: when, how, and why?
Article in Journal of molecular evolution, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 44 citations in OpenAlex.
- Anti-PECAM-1 antibodies: another tool for visualization of Reissner´s fiber and the subcommissural organ in rat central nervous system.Brain structure & function · 2026Article
- C-mannosyltransferase DPY19L1L-mediated Reissner Fiber formation is critical for zebrafish (Science advances · 2025Article
- Kv2.1 negatively regulates Reissner fiber development.Frontiers in cell and developmental biology · 2025Article
- Congenital hydrocephalus: a review of recent advances in genetic etiology and molecular mechanisms.Military Medical Research · 2024Review
- Article
- SCO-spondin knockout mice exhibit small brain ventricles and mild spine deformation.Fluids and barriers of the CNS · 2023Article
- Loss of CSF-contacting neuron sensory function is associated with a hyper-kyphosis of the spine reminiscent of Scheuermann's disease.Scientific reports · 2023Article
- The morphological and functional diversity of apical microvilli.Journal of anatomy · 2023Review
- Carbonic anhydrases in development: morphological observations and gene expression profiling in sea urchin embryos exposed to acetazolamide.Open biology · 2023Article
- SCO-spondin, a giant matricellular protein that regulates cerebrospinal fluid activity.Fluids and barriers of the CNS · 2021Review
- Camel regulates development of the brain ventricular system.Cell and tissue research · 2021Article
- The Enigmatic Reissner's Fiber and the Origin of Chordates.Frontiers in neuroanatomy · 2021Review
- Article
- The Reissner Fiber Is Highly Dynamic In Vivo and Controls Morphogenesis of the Spine.Current biology : CB · 2020Article
- Molecular insights into the powerful mucus-based adhesion of limpets (Open biology · 2020Article
- The Reissner Fiber in the Cerebrospinal Fluid Controls Morphogenesis of the Body Axis.Current biology : CB · 2018Article
- The origins of the circumventricular organs.Journal of anatomy · 2018Review
- SCO-spondin oligopeptide inhibits angiogenesis in glioblastoma.Oncotarget · 2017Article
- Understanding How the Subcommissural Organ and Other Periventricular Secretory Structures Contribute via the Cerebrospinal Fluid to Neurogenesis.Frontiers in cellular neuroscience · 2015Review
- SCO-spondin from embryonic cerebrospinal fluid is required for neurogenesis during early brain development.Frontiers in cellular neuroscience · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Subcommissural organ (SCO)-spondin is a giant glycoprotein of more than 5000 amino acids found in Vertebrata, expressed in the central nervous system and constitutive of Reissner's fiber. For the first time, in situ hybridization performed on zebrafish (Danio rerio) embryos shows that the gene encoding this protein is expressed transitionally in the floor plate, the ventral midline of the neural tube, and later in the diencephalic third ventricle roof, the SCO. The modular organization of the protein in Echinodermata (Strongylocentrotus purpuratus), Urochordata (Ciona savignyi and C. intestinalis), and Vertebrata (Teleostei, Amphibia, Aves and Mammalia) is also described. As the thrombospondin type 1 repeat motifs represent an increasingly large part of the protein during Deuterostomia evolution, the duplication mechanisms leading to this complex organization are examined. The functional significance of the particularly well-preserved arrangement of the series of SCO-spondin repeat motifs and thombospondin type 1 repeats is discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.