Trial reportEuropean journal of clinical pharmacology1991
Dose-dependent pharmacokinetics of benzoic acid following oral administration of sodium benzoate to humans.
Trial report in European journal of clinical pharmacology, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 95 citations in OpenAlex.
- Trial
- Effect of Sodium Benzoate on Cognitive Function Among Patients With Behavioral and Psychological Symptoms of Dementia: Secondary Analysis of a Randomized Clinical Trial.JAMA network open · 2021Trial
- Effects of sodium benzoate, a widely used food preservative, on glucose homeostasis and metabolic profiles in humans.Molecular genetics and metabolism · 2015Trial
- Hepatotoxic Potentials of Food Additives on Liver Enzymes and Tissues of Wistar Rats.Rwanda journal of medicine and health sciences · 2026Article
- Predicting Cumulative Neonatal Sodium Benzoate Exposures During Breastfeeding with Physiologically Based Pharmacokinetic Modelling.Clinical pharmacokinetics · 2026Article
- Vitamin C and Benzoic Acid Intake in Patients with Kidney Disease: Is There Risk of Benzene Exposure?Nutrients · 2025Review
- Impact of concerning excipients on animal safety: insights for veterinary pharmacotherapy and regulatory considerations.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2024Review
- Metabolite, protein, and tissue dysfunction associated with COVID-19 disease severity.Scientific reports · 2022Article
- Mapping of the benzoate metabolism by human gut microbiome indicates food-derived metagenome evolution.Scientific reports · 2021Article
- Breath Analysis: Comparison among Methodological Approaches for Breath Sampling.Molecules (Basel, Switzerland) · 2020Article
- The Relationship between Dietary Polyphenol Intakes and Urinary Polyphenol Concentrations in Adults Prescribed a High Vegetable and Fruit Diet.Nutrients · 2020Article
- Re-evaluation of benzyl alcohol (E 1519) as food additive.EFSA journal. European Food Safety Authority · 2019Article
- Natrium Benzoate Alleviates Neuronal Apoptosis via the DJ-1-Related Anti-oxidative Stress Pathway Involving Akt Phosphorylation in a Rat Model of Traumatic Spinal Cord Injury.Frontiers in molecular neuroscience · 2019Article
- Lysine benzoylation is a histone mark regulated by SIRT2.Nature communications · 2018Article
- The safety evaluation of food flavouring substances: the role of metabolic studies.Toxicology research · 2018Review
- Cinnamon Converts Poor Learning Mice to Good Learners: Implications for Memory Improvement.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2016Article
- Sodium Benzoate, a Food Additive and a Metabolite of Cinnamon, Enriches Regulatory T Cells via STAT6-Mediated Upregulation of TGF-β.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- A Physiologically Based Pharmacokinetic Model of Isoniazid and Its Application in Individualizing Tuberculosis Chemotherapy.Antimicrobial agents and chemotherapy · 2016Article
- D-Amino-Acid Oxidase Inhibition Increases D-Serine Plasma Levels in Mouse But not in Monkey or Dog.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Article
- Sodium Benzoate, a Metabolite of Cinnamon and a Food Additive, Upregulates Ciliary Neurotrophic Factor in Astrocytes and Oligodendrocytes.Neurochemical research · 2015Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plasma concentration-time data for benzoic and hippuric acids and urinary excretion-time data for hippuric acid were analyzed simultaneously after oral doses of 40, 80 or 160 mg/kg sodium benzoate administered at least one week apart to 6 healthy subjects. The mean AUCs of benzoic acid after the doses of 80 and 160 mg/kg of sodium benzoate were 3.7- and 12.0-times greater, respectively, than after 40 mg/kg. However, the mean AUC of hippuric acid was roughly proportional to the benzoate doses. The observed data were explained by a one-compartment model with first-order rate absorption and Michaelis-Menten elimination of benzoic acid, together with a one-compartment model with first-order elimination for hippuric acid. Although the maximum rate of biotransformation of benzoic acid to hippuric acid varied between 17.2 and 28.8 mg.kg-1.h-1 among the six individuals, the mean value (23.0 mg.kg-1.h-1) was fairly close to that provided by daily maximum dose (0.5 g.kg-1.day-1) recommended in the treatment of hyperammonaemia in patients with inborn errors of ureagenesis. The individual maximum rate of metabolism can be estimated from the urinary excretion rate of hippuric acid 1.5 to 3 h after the single oral dose of 80 to 160 mg.kg-1 sodium benzoate. The justification of this concept requires further studies in patients with inborn errors of urea synthesis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.