ArticleGenetica2008
Mutation rate and genome reduction in endosymbiotic and free-living bacteria.
Article in Genetica, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
38 citing papers in PubMed.
- Comparative pangenomics unveils distinct host adaptation trends and conserved biosynthetic potential in microbiome Clostridia.Molecular biology and evolution · 2026Article
- Deep-branching Chloroflexota lineages illuminate the eco-evolutionary foundation of cross-ecosystem colonization.Nature communications · 2026Article
- Genome Streamlining: Effect of Mutation Rate and Population Size on Genome Size Reduction.Genome biology and evolution · 2024Article
- A new lysine biosynthetic enzyme from a bacterial endosymbiont shaped by genetic drift and genome reduction.Protein science : a publication of the Protein Society · 2024Article
- Genome reduction occurred in early Prochlorococcus with an unusually low effective population size.The ISME journal · 2024Article
- Article
- Genome size distributions in bacteria and archaea are strongly linked to evolutionary history at broad phylogenetic scales.PLoS genetics · 2022Article
- Prochlorococcus have low global mutation rate and small effective population size.Nature ecology & evolution · 2022Article
- Article
- Mechanisms driving genome reduction of a novel Roseobacter lineage.The ISME journal · 2021Article
- Enhanced Mutation Rate, Relaxed Selection, and the "Domino Effect" are associated with Gene Loss in Blattabacterium, A Cockroach Endosymbiont.Molecular biology and evolution · 2021Article
- The microbiome: Composition and locations.Progress in molecular biology and translational science · 2020Review
- Adapting the engine to the fuel: mutator populations can reduce the mutational load by reorganizing their genome structure.BMC evolutionary biology · 2019Article
- Strong Purifying Selection Is Associated with Genome Streamlining in Epipelagic Marinimicrobia.Genome biology and evolution · 2019Article
- Genome Rearrangement Shapes Prochlorococcus Ecological Adaptation.Applied and environmental microbiology · 2018Article
- Comparative Genomic Analysis ofFrontiers in microbiology · 2018Article
- Mutator genomes decay, despite sustained fitness gains, in a long-term experiment with bacteria.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Excess of non-conservative amino acid changes in marine bacterioplankton lineages with reduced genomes.Nature microbiology · 2017Article
- Natural selection drove metabolic specialization of the chromatophore in Paulinella chromatophora.BMC evolutionary biology · 2017Article
- Gene Loss and Horizontal Gene Transfer Contributed to the Genome Evolution of the Extreme Acidophile "Ferrovum".Frontiers in microbiology · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genome reduction has been considered the hallmark of endosymbiotic bacteria, such as endocellular mutualists or obligatory pathogens until it was found exactly the same in several free-living bacteria. In endosymbiotic bacteria genome reduction is mainly attributed to degenerative processes due to small population size. These cannot affect the free-living bacteria with reduced genomes because they are known to have very large population sizes. It has been proposed that selection for simplification drove genome reduction in these free-living bacteria. For at least one of them (Prochlorococcus), genome reduction is associated with accelerated evolution and we suggest an alternative hypothesis based on increase in mutation rate as the primary cause of genome reduction in free-living bacteria.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.