ArticlePhotochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology2007
The effect of Tookad-mediated photodynamic ablation of the prostate gland on adjacent tissues--in vivo study in a canine model.
Article in Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 28 citations in OpenAlex.
- Histopathology of prostate tissue after vascular-targeted photodynamic therapy for localized prostate cancer.Virchows Archiv : an international journal of pathology · 2013Trial
- Recent advances in photodynamic therapy for cancer and infectious diseases.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2019Review
- Photosensitizers in prostate cancer therapy.Oncotarget · 2017Review
- Vascular targeted photochemotherapy using padoporfin and padeliporfin as a method of the focal treatment of localised prostate cancer - clinician's insight.World journal of methodology · 2016Review
- Synthesis and evaluation of cationic bacteriochlorin amphiphiles with effectiveJournal of porphyrins and phthalocyanines · 2013Article
- Stable synthetic bacteriochlorins for photodynamic therapy: role of dicyano peripheral groups, central metal substitution (2H, Zn, Pd), and Cremophor EL delivery.ChemMedChem · 2012Article
- Diffusion-weighted MRI for monitoring tumor response to photodynamic therapy.Journal of magnetic resonance imaging : JMRI · 2010Article
- Peripheral neural cell sensitivity to mTHPC-mediated photodynamic therapy in a 3D in vitro model.British journal of cancer · 2009Article
- Focal therapy for prostate cancer: revolution or evolution?BMC urology · 2009Review
- Focal treatment of prostate cancer with vascular-targeted photodynamic therapy.TheScientificWorldJournal · 2008Article
- Photodynamic therapy for treatment of solid tumors--potential and technical challenges.Technology in cancer research & treatment · 2008Review
- Photocytotoxicity of the fluorescent nonsteroidal androgen receptor ligand TDPQ.Photochemistry and photobiologyArticle
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
Abstract
Photodynamic therapy (PDT) mediated with vascular acting photosensitizer Tookad (Pd-bacteriopheophorbide) was investigated as an alternative modality for treating prostate cancer. Photodynamic effects on the prostate gland and its adjacent tissues were evaluated in a canine model. Interstitial prostate PDT was performed by irradiating individual lobes with a cylindrical diffuser fiber at various drug/light doses. The sensitivity of the adjacent tissues to Tookad PDT was determined by directly irradiating the surface of the bladder, colon, abdominal muscle and pelvic plexus with a microlens fiber at various drug/light doses. The prostate and adjacent tissues were harvested one-week after the treatment and subjected to histopathological examination. PDT-induced prostate lesions were characterized by marked hemorrhagic necrosis. The bladder, colon, abdominal muscle and pelvic plexus appeared to be sensitive to PDT although the Tookad PDT-induced responses in these tissues were minimal compared to that of the prostate gland at the same dose levels. Nevertheless, the protection of the adjacent tissues should be taken into consideration during the total prostate ablation process due to their sensitivity to PDT. The sensitivity of the prostatic urethra is worth further investigation. Direct intraurethral irradiation might provide an ideal means to determine the sensitivity of the prostatic urethra and might lead to transurethral PDT protocols for the management of benign prostatic hyperplasia (BHP).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.