ArticleJournal of perinatology : official journal of the California Perinatal Association2008
Fluid regimens in the first week of life may increase risk of patent ductus arteriosus in extremely low birth weight infants.
Article in Journal of perinatology : official journal of the California Perinatal Association, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it, 104 citations in OpenAlex.
- Chorioamnionitis and Patent Ductus Arteriosus: A Systematic Review and Meta-Analysis.PloS one · 2015Pooled it
- Total Fluid Administration and Weight Loss during the First 2 Weeks in Infants Randomized to Early Enteral Feeding after Extremely Preterm Birth.Neonatology · 2023Trial
- Postnatal maximal weight loss, fluid administration, and outcomes in extremely preterm newborns.Journal of perinatology : official journal of the California Perinatal Association · 2022Trial
- Nutrition of the preterm infant with persistent ductus arteriosus: existing evidence and practical implications.Pediatric research · 2026Review
- Standard versus restricted fluid administration in preterm infants undergoing pharmacological treatment for haemodynamically significant patent ductus arteriosus.Pediatric research · 2026Article
- Early feeding and fluid volume associations with adverse in-hospital outcomes among premature newborns.Pediatric research · 2026Article
- Association between hemodynamically significant patent ductus arteriosus and fluid intake in the first week of life in a cohort of very low birth weight preterm infants: the COOL study.European journal of pediatrics · 2025Article
- Nutritional Management for Preterm Infants with Common Comorbidities: A Narrative Review.Nutrients · 2025Review
- Third-day weight changes and bronchopulmonary dysplasia risk in preterm infants: a cohort study.Frontiers in pediatrics · 2025Article
- Advancements in research on fluid overload in preterm infants-a narrative review.Frontiers in pediatrics · 2025Review
- Factors Predicting Spontaneous Closure of Patent Ductus Arteriosus in Very Low Birth Weight Neonates.Cureus · 2024Article
- Growth and Neurodevelopmental Outcomes of Preterm Infants Born < 26 Weeks Gestation before and after Implementation of a Nutrition-Care Bundle.Children (Basel, Switzerland) · 2024Article
- Closing the Gap: Investigation of Various Approaches in the Management of Patent Ductus Arteriosus.Cureus · 2023Review
- Bronchopulmonary Dysplasia: Pathogenesis and Pathophysiology.Journal of clinical medicine · 2023Review
- Association between Fluid Balance and Treatment Outcome of Ibuprofen for Patent Ductus Arteriosus in Preterm Infants.Reviews in cardiovascular medicine · 2023Article
- Neonatal fluid overload-ignorance is no longer bliss.Pediatric nephrology (Berlin, Germany) · 2023Review
- Conservative Management of Patent Ductus Arteriosus Is Feasible in the Peri-Viable Infants at 22-25 Gestational Weeks.Biomedicines · 2022Article
- The role of furosemide and fluid management for a hemodynamically significant patent ductus arteriosus in premature infants.Journal of perinatology : official journal of the California Perinatal Association · 2022Review
- Predictors of Bronchopulmonary Dysplasia in 625 Neonates with Respiratory Distress Syndrome.Journal of tropical pediatrics · 2022Article
- Association of Weight Changes by Three Days after Birth and Mortality and/or Severe Neurological Injury in Preterm Infants < 29 Weeks Gestational Age: A Multicenter Cohort Study.Children (Basel, Switzerland) · 2022Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHigh fluid volumes may increase neonatal morbidity. However, evidence supporting fluid restriction is inconclusive and restricting fluids may restrict caloric intake.
objectiveTo determine if higher fluid intake was associated with increased risk of patent ductus arteriosus (PDA) or bronchopulmonary dysplasia (BPD) in extremely low birth weight (ELBW) infants. STUDY
designA total of 204 ELBW (<or=32 weeks, <or=1250 g) infant survivors were grouped into low-, intermediate- and high-fluid groups. chi2 analyzed proportions of subjects with and without morbidities across groups. Logistic regression quantified increased risk of PDA or BPD associated with fluid intake while controlling for confounders. Analysis of variance compared differences in caloric intake across groups.
resultAfter controlling for gestational age, severity of illness and weight change, fluid intake on day 2 (odds ratio (OR) 1.014; confidence interval (CI) 1.001 to 1.028) and day 3 (OR 1.022; CI 1.004 to 1.040) was associated with increased risk of PDA.
conclusionHigh fluid intake (>170 ml kg(-1) day(-1)) in the first days of life is associated with increased risk of PDA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.