ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2007
Polarity-regulating kinase partitioning-defective 1/microtubule affinity-regulating kinase 2 negatively regulates development of dendrites on hippocampal neurons.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 51 citations in OpenAlex.
- Case Report: Epileptic phenotype in a patient with aFrontiers in pediatrics · 2026Article
- MARK2 variants cause autism spectrum disorder via the downregulation of WNT/β-catenin signaling pathway.American journal of human genetics · 2024Article
- MARK2 phosphorylates KIF13A at a 14-3-3 binding site to polarize vesicular transport of transferrin receptor within dendrites.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- MARK2 regulates directed cell migration through modulation of myosin II contractility and focal adhesion organization.Current biology : CB · 2022Article
- Exposure to Di-(2-ethylhexyl) Phthalate During Perinatal Period Gender-Specifically Impairs the Dendritic Growth of Pyramidal Neurons in Rat Offspring.Frontiers in neuroscience · 2018Article
- Cell Polarity in Cerebral Cortex Development-Cellular Architecture Shaped by Biochemical Networks.Frontiers in cellular neuroscience · 2017Review
- Unique ability of pandemic influenza to downregulate the genes involved in neuronal disorders.Molecular biology reports · 2015Article
- The effects of early-life seizures on hippocampal dendrite development and later-life learning and memory.Brain research bulletin · 2014Review
- Emerging modes of PINK1 signaling: another task for MARK2.Frontiers in molecular neuroscience · 2014Review
- Shootin1 acts in concert with KIF20B to promote polarization of migrating neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Molecular mechanisms of dendrite morphogenesis.Frontiers in cellular neuroscience · 2012Article
- Phosphorylation of Kif26b promotes its polyubiquitination and subsequent proteasomal degradation during kidney development.PloS one · 2012Article
- A novel function of the cell polarity-regulating kinase PAR-1/MARK in dendritic spines.Bioarchitecture · 2011Article
- DAPK activates MARK1/2 to regulate microtubule assembly, neuronal differentiation, and tau toxicity.Cell death and differentiation · 2011Article
- Attenuated CagA oncoprotein in Helicobacter pylori from Amerindians in Peruvian Amazon.The Journal of biological chemistry · 2011Article
- Maintenance of dendritic spine morphology by partitioning-defective 1b through regulation of microtubule growth.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- RIP2-mediated LKB1 deletion causes axon degeneration in the spinal cord and hind-limb paralysis.Disease models & mechanisms · 2011Article
- TRESK background K(+) channel is inhibited by PAR-1/MARK microtubule affinity-regulating kinases in Xenopus oocytes.PloS one · 2011Article
- Amacrine cell gene expression and survival signaling: differences from neighboring retinal ganglion cells.Investigative ophthalmology & visual science · 2010Article
- Nucleoredoxin negatively regulates Toll-like receptor 4 signaling via recruitment of flightless-I to myeloid differentiation primary response gene (88).The Journal of biological chemistry · 2010Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neurons are highly polarized cells that possess two morphologically and functionally different types of protrusions, axons and dendrites, that function in the transmission and reception of neural signals, respectively. A great deal of attention has been paid to the specification and guidance of axons, but the mechanism of dendrite development remains mostly unknown. We report here that a polarity-regulating kinase, partitioning-defective 1 (Par1b)/microtubule affinity-regulating kinase 2 (MARK2), specifically regulates development of dendrites in hippocampal neurons. Ectopic expression of Par1b/MARK2 shortens the length and decreases branching of dendrites without significant effects on axons. Knockdown of endogenous Par1b/MARK2 by RNA interference stimulates dendrite development. Wnt stimulation and Dishevelled expression, both of which are known to induce dendrite development, induced recruitment of Par1b/MARK2 to the membrane fraction. Expression of a Par1b/MARK2 mutant, that contains a myristoylation signal and accumulates exclusively in membranes, does not affect dendrite development. In addition, Par1b/MARK2 efficiently phosphorylated MAP2, which is localized mainly in dendrites. These results indicate that Par1b/MARK2 negatively regulates dendrite development through phosphorylation of MAP2.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.