ArticleJournal of neuroscience methods2008
Making quantal analysis more convenient, fast, and accurate: user-friendly software QUANTAN.
Article in Journal of neuroscience methods, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 22 citations in OpenAlex.
- Kismet/CHD7/CHD8 and Amyloid Precursor Protein-like Regulate Synaptic Levels of Rab11 at theInternational journal of molecular sciences · 2024Article
- Synapsin II Directly Suppresses Epileptic Seizures In Vivo.Brain sciences · 2022Article
- Stochastic Properties of Spontaneous Synaptic Transmission at Individual Active Zones.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- The CD63 homologs, Tsp42Ee and Tsp42Eg, restrict endocytosis and promote neurotransmission through differential regulation of synaptic vesicle pools.Frontiers in cellular neuroscience · 2022Article
- Growth and excitability at synapsin II deficient hippocampal neurons.Molecular and cellular neurosciences · 2019Article
- Focal Macropatch Recordings of Synaptic Currents from the Drosophila Larval Neuromuscular Junction.Journal of visualized experiments : JoVE · 2017Article
- Electrophysiological analysis of synaptic transmission in Drosophila.Wiley interdisciplinary reviews. Developmental biology · 2017Review
- Synapsin II Regulation of GABAergic Synaptic Transmission Is Dependent on Interneuron Subtype.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Interaction of the Complexin Accessory Helix with Synaptobrevin Regulates Spontaneous Fusion.Biophysical journal · 2016Article
- Synchronization of action potentials during low-magnesium-induced bursting.Journal of neurophysiology · 2015Article
- Synapsin II and Rab3a cooperate in the regulation of epileptic and synaptic activity in the CA1 region of the hippocampus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Interaction of the complexin accessory helix with the C-terminus of the SNARE complex: molecular-dynamics model of the fusion clamp.Biophysical journal · 2013Article
- Synapsin regulates vesicle organization and activity-dependent recycling at Drosophila motor boutons.Neuroscience · 2010Article
- Cooperative regulation of neurotransmitter release by Rab3a and synapsin II.Molecular and cellular neurosciences · 2010Article
- Stimulation-induced formation of the reserve pool of vesicles in Drosophila motor boutons.Journal of neurophysiology · 2009Article
- Enhancement of the endosomal endocytic pathway increases quantal size.Molecular and cellular neurosciences · 2009Article
- Synapsin II and calcium regulate vesicle docking and the cross-talk between vesicle pools at the mouse motor terminals.The Journal of physiology · 2008Article
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Quantal analysis of synaptic transmission is an important tool for understanding the mechanisms of synaptic plasticity and synaptic regulation. Although several custom-made and commercial algorithms have been created for the analysis of spontaneous synaptic activity, software for the analysis of action potential evoked release remains very limited. The present paper describes a user-friendly software package QUANTAN which has been created to analyze electrical recordings of postsynaptic responses. The program package is written using Borland C++ under Windows platform. QUANTAN employs and compares several algorithms to extract the average quantal content of synaptic responses, including direct quantal counts, the analysis of synaptic amplitudes, and the analysis of integrated current traces. The integration of several methods in one user-friendly program package makes quantal analysis of action potential evoked release more reliable and accurate. To evaluate the variability in quantal content, QUANTAN performs deconvolution of the distributions of amplitudes or areas of synaptic responses employing a ridge regression method. Other capabilities of QUANTAN include the analysis of the time-course and stationarity of quantal release. In summary, QUANTAN uses digital records of synaptic responses as an input and computes the distribution of quantal content and synaptic parameters. QUANTAN is freely available to other scholars over the internet.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.