ArticleCell2007
Induction of pluripotency: from mouse to human.
Article in Cell, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 59 citations in OpenAlex.
- Advancing Congenital Heart Defect Treatments: Synergistic Approaches with Stem Cells and Functional Scaffolds.Stem cell reviews and reports · 2026Review
- Stem cells and bio scaffolds for the treatment of cardiovascular diseases: new insights.Frontiers in cell and developmental biology · 2024Review
- Great Expectations: Induced pluripotent stem cell technologies in neurodevelopmental impairments.International journal of medical sciences · 2021Review
- MEIS1 promotes expression of stem cell markers in esophageal squamous cell carcinoma.BMC cancer · 2020Article
- Advances in regenerative therapy: A review of the literature and future directions.Regenerative therapy · 2020Review
- Engineered circulatory scaffolds for building cardiac tissue.Journal of thoracic disease · 2018Review
- Perspectives and Challenges of Pluripotent Stem Cells in Cardiac Arrhythmia Research.Current cardiology reports · 2017Review
- Induced pluripotent stem cells in dentistry.Journal of pharmacy & bioallied sciences · 2016Review
- Adipose-Derived Stem Cells for Tissue Engineering and Regenerative Medicine Applications.Stem cells international · 2016Review
- Recent technological updates and clinical applications of induced pluripotent stem cells.The Korean journal of internal medicine · 2014Review
- Network analysis of transcription factors for nuclear reprogramming into induced pluripotent stem cell using bioinformatics.Cell journal · 2014Article
- Epigenetic marks define the lineage and differentiation potential of two distinct neural crest-derived intermediate odontogenic progenitor populations.Stem cells and development · 2013Article
- iPS cells generation: an overview of techniques and methods.Journal of stem cells & regenerative medicine · 2013Article
- Generation of induced pluripotent stem cells from human nasal epithelial cells using a Sendai virus vector.PloS one · 2012Article
- Specific detection of OCT3/4 isoform A/B/B1 expression in solid (germ cell) tumours and cell lines: confirmation of OCT3/4 specificity for germ cell tumours.British journal of cancer · 2011Article
- The structure of the Klf4 DNA-binding domain links to self-renewal and macrophage differentiation.Cellular and molecular life sciences : CMLS · 2011Article
- Obtaining consent for future research with induced pluripotent cells: opportunities and challenges.PLoS biology · 2009Article
- Induced pluripotent stem cells, new tools for drug discovery and new hope for stem cell therapies.Current molecular pharmacology · 2009Review
- Extensive genomic copy number variation in embryonic stem cells.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
Corrections and comments
- Comment on
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this issue of Cell, Takahashi et al. (2007) transfer their seminal work on somatic cell reprogramming from the mouse to human. By overexpressing the transcription factor quartet of Oct4, Sox2, Klf4, and c-Myc in adult human fibroblasts, they successfully isolate human pluripotent stem cells that resemble human embryonic stem cells by all measured criteria. This is a significant turning point in nuclear reprogramming research with broad implications for generating patient-specific pluripotent stem cells for research and therapeutic applications.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.