ArticleGenome biology2007
Integrative analysis for finding genes and networks involved in diabetes and other complex diseases.
Article in Genome biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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Who cites it
31 citing papers in PubMed.
- A Dual Systems Genetics Approach Identifies Common Genes, Networks, and Pathways for Type 1 and 2 Diabetes in Human Islets.Frontiers in genetics · 2021Article
- Protein-Protein interactions uncover candidate 'core genes' within omnigenic disease networks.PLoS genetics · 2020Article
- Review
- Network-based logistic regression integration method for biomarker identification.BMC systems biology · 2018Article
- Type 1 diabetes genome-wide association studies: not to be lost in translation.Clinical & translational immunology · 2017Review
- Genes affecting β-cell function in type 1 diabetes.Current diabetes reports · 2015Review
- Insights from systems pharmacology into cardiovascular drug discovery and therapy.BMC systems biology · 2014Article
- Protein-protein interactions and genetic diseases: The interactome.Biochimica et biophysica acta · 2014Review
- Hope for GWAS: relevant risk genes uncovered from GWAS statistical noise.International journal of molecular sciences · 2014Article
- Protein-protein interaction networks (PPI) and complex diseases.Gastroenterology and hepatology from bed to bench · 2014Review
- Structure and dynamics of molecular networks: a novel paradigm of drug discovery: a comprehensive review.Pharmacology & therapeutics · 2013Review
- Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.Cell reports · 2012Article
- Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.Nature communications · 2012Article
- Bridging the Gap between Genotype and Phenotype via Network Approaches.Frontiers in genetics · 2012Article
- Insights into the pathogenesis of axial spondyloarthropathy from network and pathway analysis.BMC systems biology · 2012Article
- Large-scale de novo prediction of physical protein-protein association.Molecular & cellular proteomics : MCP · 2011Article
- The molecular pathogenesis of HIV-1 associated nephropathy: recent advances.Journal of molecular medicine (Berlin, Germany) · 2011Review
- Initial characterization of the human central proteome.BMC systems biology · 2011Article
- Proteins encoded in genomic regions associated with immune-mediated disease physically interact and suggest underlying biology.PLoS genetics · 2011Article
- Genetics of type 1 diabetes: what's next?Diabetes · 2010Review
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
We have developed an integrative analysis method combining genetic interactions, identified using type 1 diabetes genome scan data, and a high-confidence human protein interaction network. Resulting networks were ranked by the significance of the enrichment of proteins from interacting regions. We identified a number of new protein network modules and novel candidate genes/proteins for type 1 diabetes. We propose this type of integrative analysis as a general method for the elucidation of genes and networks involved in diabetes and other complex diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.