ArticleBMC cancer2007
A comparative study between mixed-type tumours from human salivary and canine mammary glands.
Article in BMC cancer, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 33 citations in OpenAlex.
- Article
- Canine, Feline, and Murine Mammary Tumors as a Model for Translational Research in Breast Cancer.Veterinary sciences · 2025Review
- A Comparative Review of Mixed Mammary Tumors in Mammals.Journal of mammary gland biology and neoplasia · 2019Review
- HER-2 and EGFR mRNA Expression and Its Relationship with Versican in Malignant Matrix-Producing Tumors of the Canine Mammary Gland.PloS one · 2016Article
- Breast lesions of uncertain malignant nature and limited metastatic potential: proposals to improve their recognition and clinical management.Histopathology · 2016Review
- Versican expression in canine carcinomas in benign mixed tumours: is there an association with clinical pathological factors, invasion and overall survival?BMC veterinary research · 2012Article
- Oncolytic virotherapy in veterinary medicine: current status and future prospects for canine patients.Journal of translational medicine · 2012Review
- Canine mammary mixed tumours: a review.Veterinary medicine international · 2012Article
- Morphological aspects and immunophenotypic profiles of mammary carcinomas in benign-mixed tumors of female dogs.Veterinary medicine international · 2012Article
- Extramedullary hematopoiesis in a case of benign mixed mammary tumor in a female dog: cytological and histopathological assessment.BMC veterinary research · 2010Article
- Immunophenotypic features of tumor infiltrating lymphocytes from mammary carcinomas in female dogs associated with prognostic factors and survival rates.BMC cancer · 2010Article
- Columnar cell lesions of the canine mammary gland: pathological features and immunophenotypic analysis.BMC cancer · 2010Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn comparative pathology, canine mammary tumours have special interest because of their similarities with human breast cancer. Mixed tumours are uncommon lesions in the human breast, but they are found most frequently in the mammary gland of the female dogs and in the human salivary glands. The aim of the study was to compare clinical, morphological and immunohistochemical features of human salivary and canine mammary gland mixed tumours, in order to evaluate the latter as an experimental model for salivary gland tumours.
methodsTen examples of each mixed tumour type (human pleomorphic adenoma and carcinomas ex-pleomorphic adenomas and canine mixed tumour and metaplastic carcinoma) were evaluated. First, clinical and morphologic aspects of benign and malignant variants were compared between the species. Then, streptavidin-biotin-peroxidase immunohistochemistry was performed to detect the expression of cytokeratins, vimentin, p63 protein, estrogen receptor, beta-catenin, and E-cadherin.
resultsAfter standardization, similar age and site distributions were observed in human and canine tumours. Histological similarities were identified in the comparison of the benign lesions as well. Metaplastic carcinomas also resembled general aspects of carcinomas ex-pleomorphic adenomas in morphological evaluation. Additionally, immunohistochemical staining further presented similar antigenic expression between lesions.
conclusionThere are many similar features between human salivary and canine mammary gland mixed tumours. This observation is of great relevance for those interested in the study and management of salivary gland tumours, since canine lesions may constitute useful comparative models for their investigations.
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