ArticleNeural computation2008
Irregular firing of isolated cortical interneurons in vitro driven by intrinsic stochastic mechanisms.
Article in Neural computation, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Stochastic and deterministic dynamics of intrinsically irregular firing in cortical inhibitory interneurons.eLife · 2016Article
- What is all the noise about in interval timing?Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2014Article
- The ISI distribution of the stochastic Hodgkin-Huxley neuron.Frontiers in computational neuroscience · 2014Article
- Why noise is useful in functional and neural mechanisms of interval timing?BMC neuroscience · 2013Article
- Origin of intrinsic irregular firing in cortical interneurons.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- How noise contributes to time-scale invariance of interval timing.Physical review. E, Statistical, nonlinear, and soft matter physics · 2013Article
- Striatal fast-spiking interneurons: from firing patterns to postsynaptic impact.Frontiers in systems neuroscience · 2011Article
- Dynamics of excitability over extended timescales in cultured cortical neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Period-doubling bifurcation in an array of coupled stochastically excitable elements subjected to global periodic forcing.Physical review letters · 2009Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Pharmacologically isolated GABAergic irregular spiking and stuttering interneurons in the mouse visual cortex display highly irregular spike times, with high coefficients of variation approximately 0.9-3, in response to a depolarizing, constant current input. This is in marked contrast to cortical pyramidal cells, which spike quite regularly in response to the same current injection. We applied time-series analysis methods to show that the irregular behavior of the interneurons was not a consequence of low-dimensional, deterministic processes. These methods were also applied to the Hindmarsh and Rose neuronal model to confirm that the methods are adequate for the types of data under investigation. This result has important consequences for the origin of fluctuations observed in the cortex in vivo.
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Registered trials
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