ArticleBiochemistry2007
Myristoyl-based transport of peptides into living cells.
Article in Biochemistry, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed.
- Structure-based discovery of hydrocarbon-stapled paxillin peptides that block FAK scaffolding in cancer.Nature communications · 2025Article
- Fatty Acid Derivatization and Cyclization of the Immunomodulatory Peptide RP-182 Targeting CD206high Macrophages Improve Antitumor Activity.Molecular cancer therapeutics · 2024Article
- Synaptic memory requires CaMKII.eLife · 2021Article
- Fatty acylation enhances the cellular internalization and cytosolic distribution of a cystine-knot peptide.iScience · 2021Article
- Myristic Acid Serum Levels and Their Significance for Diagnosis of Systemic Inflammatory Response, Sepsis, and Bacteraemia.Journal of personalized medicine · 2021Article
- Pseudopeptide Amyloid Aggregation Inhibitors: In Silico, Single Molecule and Cell Viability Studies.International journal of molecular sciences · 2021Article
- Article
- Myristoylated TMEM39AS41, a cell-permeable peptide, causes lung cancer cell death.Toxicological research · 2020Article
- βAnnual review of pharmacology and toxicology · 2020Review
- Magi-1 scaffolds NaFASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- A review of lipidation in the development of advanced protein and peptide therapeutics.Journal of controlled release : official journal of the Controlled Release Society · 2019Review
- Novel peptide myristoly-CM4 induces selective cytotoxicity in leukemia K562/MDR and Jurkat cells by necrosis and/or apoptosis pathway.Drug design, development and therapy · 2019Article
- Targeting the CALR interactome in myeloproliferative neoplasms.JCI insight · 2018Article
- Design and Application of Sensors for Chemical Cytometry.ACS chemical biology · 2018Review
- Combined inhibition of MEK and nuclear ERK translocation has synergistic antitumor activity in melanoma cells.Scientific reports · 2017Article
- CDK5-mediated phosphorylation of XBP1s contributes to its nuclear translocation and activation in MPPScientific reports · 2017Article
- Protein kinase Cɛ activity regulates mGluR5 surface expression in the rat nucleus accumbens.Journal of neuroscience research · 2017Article
- Toll-like Receptors in the Vascular System: Sensing the Dangers Within.Pharmacological reviews · 2016Review
- Amphiphilic Lipopeptide-Mediated Transport of Insulin and Cell Membrane Penetration Mechanism.Molecules (Basel, Switzerland) · 2015Article
- Accessible Synthetic Probes for Staining Actin inside Platelets and Megakaryocytes by Employing Lifeact Peptide.Chembiochem : a European journal of chemical biology · 2015Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Translocation of membrane-impermeant molecules to the interior of living cells is a necessity for many biochemical investigations. Myristoylation was studied as a means to introduce peptides into living cells. Uptake of a myristoylated, fluorescent peptide was efficient in the B lymphocyte cell line BA/F3. In contrast, this cell line was resistant to uptake of a cell-penetrating peptide derived from the TAT protein. In BA/F3 cells, membrane association was shown to be rapid, reaching a maximum within 30 min. Cellular uptake of the peptide lagged the membrane association but occurred within a similar time frame. Experiments performed at 37 versus 4 degrees C demonstrated profound temperature dependence in the cellular uptake of myristoylated cargo. Myristoylated peptides with either positive or negative charge were shown to load efficiently. In contrast to TAT-conjugated cargo, pyrenebutyrate did not enhance cellular uptake of the myristoylated peptide. The myristoylated peptide did not adversely affect cell viability at concentrations up to 100 muM. This assessment of myristoyl-based transport provides fundamental data needed in understanding the intracellular delivery of myristoylated peptide cargoes for cell-based biochemical studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.