ReviewClinical interventions in aging2007
Long-term management of GERD in the elderly with pantoprazole.
Review in Clinical interventions in aging, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effect of long-term proton pump inhibitor administration on gastric mucosal atrophy: A meta-analysis.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology AssociationPooled it
- Neurological Manifestations Associated With Hypomagnesemia Due to Proton-Pump Inhibitors: A Case Series.Cureus · 2025Article
- Inappropriate Use of Proton Pump Inhibitor Among Elderly Patients in British Columbia: What are the Long-term Adverse Events?Current drug safety · 2024Article
- Review
- Personalized Treatments Based on Laryngopharyngeal Reflux Patient Profiles: A Narrative Review.Journal of personalized medicine · 2023Review
- Treating and Managing Laryngopharyngeal Reflux Disease in the Over 65s: Evidence to Date.Clinical interventions in aging · 2022Review
- Diagnostic value of endoscopy in adult patients with dyspepsia.Przeglad gastroenterologiczny · 2022Article
- Management of Gastroesophageal Reflux Disease in the Elderly Patient.Drugs & aging · 2019Review
- In vitro effect of pantoprazole on lower esophageal sphincter tone in rats.World journal of gastroenterology · 2011Article
- Patient and physician satisfaction with proton pump inhibitors (PPIs): are there opportunities for improvement?Digestive diseases and sciences · 2010Article
- The safety of drugs used in acid-related disorders and functional gastrointestinal disorders.Gastroenterology clinics of North America · 2010Review
- An update on the use of pantoprazole as a treatment for gastroesophageal reflux disease.Clinical and experimental gastroenterology · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The prevalence of gastroesophageal reflux disease (GERD) increases with age and elderly are more likely to develop severe disease. Older patients often complain of less severe or frequent heartburn than younger patients and they may present with atypical symptoms such as dysphagia, weight loss, or extraesophageal symptoms. Proton pump inhibitors (PPIs) are central in the management of GERD and are unchallenged with regards to their efficacy. They are considered safe and more effective than histamine receptor antagonists for healing esophagitis and for preventing its recurrence using a long term maintenance treatment. PPI have minimal side effects and few slight drug interactions and are considered safe for long term treatment. Pantoprazole is significantly effective both for acute and long-term treatment with excellent control of relapse and symptoms. It is well tolerated even for long-term therapy and its tolerability is optimal. Pantoprazole shows to have minimal interactions with other drugs because of a lower affinity for cytocrome P450 than older PPIs. Although the majority of elderly has concomitant illnesses and receive other drugs, this does not adversely effect the efficacy of pantoprazole because of its pharmacokinetics, which are independent of patient age. Clinical practice suggests that a low dose maintenance of PPIs should be used in older patients with GERD.
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