ReviewClinical interventions in aging2007
Immunological outcomes of exercise in older adults.
Review in Clinical interventions in aging, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 97 citations in OpenAlex.
- Pooled it
- Benefits of Exercise on Influenza or Pneumonia in Older Adults: A Systematic Review.International journal of environmental research and public health · 2020Pooled it
- Tolerability of glutamine supplementation in older adults: a double-blind placebo-controlled randomized clinical trial.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2024Trial
- Influence of physical activity on the immune system in breast cancer patients during chemotherapy.Journal of cancer research and clinical oncology · 2018Trial
- Protective effect of regular physical activity on major depressive episodes in patients with early stages of chronic kidney disease.Renal failure · 2017Trial
- Salutary effects of moderate but not high intensity aerobic exercise training on the frequency of peripheral T-cells associated with immunosenescence in older women at high risk of breast cancer: a randomized controlled trial.Immunity & ageing : I & A · 2022Article
- The Effects of Exercise on Aging-Induced Exaggerated Cytokine Responses: An Interdisciplinary Discussion.Scientifica · 2022Review
- Women's Lives Matter-The Critical Need for Women to Prioritize Optimal Physical Activity to Reduce COVID-19 Illness Risk and Severity.International journal of environmental research and public health · 2021Review
- Lymphocytes as a Biomarker of Frailty Syndrome: A Scoping Review.Diseases (Basel, Switzerland) · 2021Article
- Sustaining efficient immune functions with regular physical exercise in the COVID-19 era and beyond.European journal of clinical investigation · 2021Review
- Lifestyle exercise attenuates immunosenescence; flow cytometry analysis.BMC geriatrics · 2021Article
- COVID-19: sitting is the new smoking; the role of exercise in augmenting the immune system among the elderly.African health sciences · 2021Article
- Effects of Acute and Chronic Exercise on Immunological Parameters in the Elderly Aged: Can Physical Activity Counteract the Effects of Aging?Frontiers in immunology · 2018Review
- Allergic diseases in the elderly: biological characteristics and main immunological and non-immunological mechanisms.Clinical and molecular allergy : CMA · 2017Review
- The serum protein profile of early parity which induces protection against breast cancer.Oncotarget · 2016Article
- CD56(dim)CD16(high) and CD56(bright)CD16(-) cell percentages associated with maximum knee extensor strength and incidence of death in elderly.SpringerPlus · 2016Article
- Elderly men with moderate and intense training lifestyle present sustained higher antibody responses to influenza vaccine.Age (Dordrecht, Netherlands) · 2015Article
- HSC Aging and Senescent Immune Remodeling.Trends in immunology · 2015Review
- Adaptation to Resistance Training Is Associated with Higher Phagocytic (but Not Oxidative) Activity in Neutrophils of Older Women.Journal of immunology research · 2015Article
- Evidence for anti-inflammatory effects of exercise in CKD.Journal of the American Society of Nephrology : JASN · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aging is associated with a dysregulation of the immune system known as immunosenescence. Immunosenescence involves cellular and molecular alterations that impact both innate and adaptive immunity, leading to increased incidences of infectious disease morbidity and mortality as well as heightened rates of other immune disorders such as autoimmunity, cancer, and inflammatory conditions. While current data suggests physical activity may be an effective and logistically easy strategy for counteracting immunosenescence, it is currently underutilized in clinical settings. Long-term, moderate physical activity interventions in geriatric populations appear to be associated with several benefits including reduction in infectious disease risk, increased rates of vaccine efficacy, and improvements in both physical and psychosocial aspects of daily living. Exercise may also represent a viable therapy in patients for whom pharmacological treatment is unavailable, ineffective, or inappropriate. The effects of exercise impact multiple aspects of immune response including T cell phenotype and proliferation, antibody response to vaccination, and cytokine production. However, an underlying mechanism by which exercise affects numerous cell types and responses remains to be identified. Given this evidence, an increase in the use of physical activity programs by the healthcare community may result in improved health of geriatric populations.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.