ArticleJournal of bioenergetics and biomembranes2007
Na,K-ATPase and the role of alpha isoforms in behavior.
Article in Journal of bioenergetics and biomembranes, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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Who cites it
47 citing papers in PubMed, 94 citations in OpenAlex.
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- The natural compound periplogenin suppresses the growth of prostate carcinoma cells by directly targeting ATP1A1.Scientific reports · 2024Article
- Sensational site: the sodium pump ouabain-binding site and its ligands.American journal of physiology. Cell physiology · 2024Review
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- Knockdown of the Sodium/Potassium ATPase Subunit Beta 2 Reduces Egg Production in the Dengue Vector,Insects · 2023Article
- NaAntioxidants (Basel, Switzerland) · 2022Article
- Effect of handling on ATP utilization of cerebral Na,K-ATPase in rats with trimethyltin-induced neurodegeneration.Molecular and cellular biochemistry · 2021Article
- Downregulation of ATP1A1 Expression byFrontiers in pharmacology · 2021Article
- Ouabain-Induced Cell Death and Survival. Role of α1-Na,K-ATPase-Mediated Signaling and [NaFrontiers in physiology · 2020Review
- A Transgenic Mouse Model to Selectively Identify αNeuroscience · 2019Article
- Na⁺, K⁺-ATPase Signaling and Bipolar Disorder.International journal of molecular sciences · 2018Review
- Novel pregnancy-triggered episodes of CAPOS syndrome.American journal of medical genetics. Part A · 2018Review
- The loss-of-function disease-mutation G301R in the NaBMC neuroscience · 2017Article
- Anthocyanins control neuroinflammation and consequent memory dysfunction in mice exposed to lipopolysaccharide.Molecular neurobiology · 2017Article
- Polyamines regulate phosphorylation-dephosphorylation kinetics in a crustacean gill (NaMolecular and cellular biochemistry · 2017Article
- Src-independent ERK signaling through the rat α3 isoform of Na/K-ATPase.American journal of physiology. Cell physiology · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The Na,K-ATPase is composed of multiple isoforms and the isoform distribution varies with the tissue and during development. The alpha1 isoform for example, is the major isoform in the kidney and many other tissues, while the alpha2 isoform is the predominate one in skeletal muscle. All three isoforms are found in the brain although in adult rodent brain, the alpha 3 isoform is located essentially in neurons while the alpha2 isoform is found in astrocytes and some limited neuronal populations. Interestingly the alpha 4 isoform is found exclusively in the mid region of the sperm tail. The distribution of the isoforms of the Na,K-ATPase has been extensively studied in many tissues and during development. The examples cited above provide some indication to the diversity of Na,K-ATPase isoform expression. In order to understand the significance of this distribution, we have developed animals which lack the alpha1, alpha2, and alpha 3 isoforms. It is anticipated that these studies will provide insight into the role that these isoforms play in driving various biological processes in specific tissues. Here we describe some of our studies which deal with the behavioral aspects of the alpha1, alpha2, and alpha 3 deficient mice, particularly those that are haploinsufficient in one isoform i.e. lacking one functional gene for the alpha1, alpha2, or alpha 3 isoforms. Such studies are important as two human diseases are associated with deficiency in the alpha2 and alpha 3 isoforms. These are Familial Hemiplegic Migraine type 2 and Rapid-Onset Dystonia Parkinsonism, these diseases result from alpha2 and alpha 3 isoform haploinsufficiency, respectively. We find that the haploinsufficiency of both alpha2 and alpha 3 isoforms result in behavioral defects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.