ReviewInternal and emergency medicine2007
CD40/CD40L system and vascular disease.
Review in Internal and emergency medicine, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 99 citations in OpenAlex.
- Time for a More Precise and Practical Laboratory Definition of Metainflammation in Obesity-Related Diseases.Medical sciences (Basel, Switzerland) · 2026Article
- Hyper-reactive platelets and type 2 diabetes.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2022Article
- Targeting Platelet Activation in Abdominal Aortic Aneurysm: Current Knowledge and Perspectives.Biomolecules · 2022Review
- Candidate Biomarkers for Specific Intraoperative Near-Infrared Imaging of Soft Tissue Sarcomas: A Systematic Review.Cancers · 2021Review
- Portal vein thrombosis and food protein-induced allergic proctocolitis in a premature newborn with hypereosinophilia: a case report.BMC pediatrics · 2021Article
- Hypereosinophilia with Concurrent Venous Thromboembolism: Clinical Features, Potential Risk Factors, and Short-term Outcomes in a Chinese Cohort.Scientific reports · 2020Article
- Utility of Carotid Intima-Media Thickness as an Auxiliary Vascular Parameter of Structural Alteration in Ulcerative Colitis.Inflammatory intestinal diseases · 2019Article
- Impacts of Cancer on Platelet Production, Activation and Education and Mechanisms of Cancer-Associated Thrombosis.Cancers · 2018Review
- Relationship Between Plasma Levels of Soluble CD40 Ligand and the Presence and Severity of Isolated Coronary Artery Ectasia.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis · 2018Article
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- Reproducibility over time and effect of low-dose aspirin on soluble P-selectin and soluble CD40 ligand.Journal of thrombosis and thrombolysis · 2015Article
- Inflammation and hypertension: new understandings and potential therapeutic targets.Current hypertension reports · 2015Review
- Enhanced tissue factor expression by blood eosinophils from patients with hypereosinophilia: a possible link with thrombosis.PloS one · 2014Article
- Clinical marker of platelet hyperreactivity in diabetes mellitus.Diabetes & metabolism journal · 2013Article
- Increased pulse wave velocity and carotid intima-media thickness in patients with ulcerative colitis.Digestive diseases and sciences · 2013Article
- Platelets, oxidative stress and preservation of the vascular endothelium: is it a matter of fat?Internal and emergency medicine · 2012Article
- The prothrombotic tendency in metabolic syndrome: focus on the potential mechanisms involved in impaired haemostasis and fibrinolytic balance.Scientifica · 2012Review
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- Crucial role of CD40 signaling in vascular wall cells in neointimal formation and vascular remodeling after vascular interventions.Arteriosclerosis, thrombosis, and vascular biology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Several distinct lines of investigation in the context of atherosclerosis dealing with low-grade inflammation, oxidative stress and platelet activation are now emerging, with CD40/CD40L system as the missing link. CD40 ligand is a transmembrane glycoprotein structurally related to tumour necrosis factor-alpha and more than 95% of the circulating CD40L derives from platelets. CD40L appears as a multiplayer of several cell types in the inflammatory network. The peculiarity of CD40L as an inflammatory mediator derived from platelets expands the functional repertoire of platelets from players of haemostasis and thrombosis to powerful amplifiers of inflammation by promoting the release of cytokines and chemokines, cell activation and cell-cell interactions. The multifunctional role of CD40L, as a simultaneous activator of all these systems, further blurs the intricate relationship between such events both in the physiological systems and the pathological derangement occurring in atherothrombosis.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.