ArticlePloS one2007
Mosaic genome architecture of the Anopheles gambiae species complex.
Article in PloS one, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- High-resolution species assignment ofeLife · 2022Article
- Ghost lineages can invalidate or even reverse findings regarding gene flow.PLoS biology · 2022Article
- A targeted amplicon sequencing panel to simultaneously identify mosquito species and Plasmodium presence across the entire Anopheles genus.Molecular ecology resources · 2022Article
- Insights Into an Unexplored Component of the Mosquito Repeatome: Distribution and Variability of Viral Sequences Integrated Into the Genome of the Arboviral VectorFrontiers in genetics · 2019Article
- Coalescent Analysis of Phylogenomic Data Confidently Resolves the Species Relationships in the Anopheles gambiae Species Complex.Molecular biology and evolution · 2018Article
- Phylogenetic signal from rearrangements in 18 Anopheles species by joint scaffolding extant and ancestral genomes.BMC genomics · 2018Article
- Article
- Genetic Structure of a Local Population of the Anopheles gambiae Complex in Burkina Faso.PloS one · 2016Article
- Reticulate Speciation and Barriers to Introgression in the Anopheles gambiae Species Complex.Genome biology and evolution · 2015Article
- A new multiplex SNP genotyping assay for detecting hybridization and introgression between the M and S molecular forms of Anopheles gambiae.Molecular ecology resources · 2014Article
- Evidence for the occurrence of two sympatric sibling species within the Anopheles (Kerteszia) cruzii complex in southeast Brazil and the detection of asymmetric introgression between them using a multilocus analysis.BMC evolutionary biology · 2013Article
- No evidence for positive selection at two potential targets for malaria transmission-blocking vaccines in Anopheles gambiae s.s.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2013Article
- Chromosome inversions, genomic differentiation and speciation in the African malaria mosquito Anopheles gambiae.PloS one · 2013Article
- Multilocus analysis of divergence and introgression in sympatric and allopatric sibling species of the Lutzomyia longipalpis complex in Brazil.PLoS neglected tropical diseases · 2013Article
- Molecular characterization and evolution of a gene family encoding male-specific reproductive proteins in the African malaria vector Anopheles gambiae.BMC evolutionary biology · 2011Article
- Evolutionary factors affecting Lactate dehydrogenase A and B variation in the Daphnia pulex species complex.BMC evolutionary biology · 2011Article
- Article
- Leveraging skewed transcript abundance by RNA-Seq to increase the genomic depth of the tree of life.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Molecular evidence for the occurrence of a new sibling species within the Anopheles (Kerteszia) cruzii complex in south-east Brazil.Malaria journal · 2010Article
- Inferring selection in the Anopheles gambiae species complex: an example from immune-related serine protease inhibitors.Malaria journal · 2009Article
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Authors and funding
11 authors.
Funding
Abstract
backgroundAttempts over the last three decades to reconstruct the phylogenetic history of the Anopheles gambiae species complex have been important for developing better strategies to control malaria transmission. METHODOLOGY: We used fingerprint genotyping data from 414 field-collected female mosquitoes at 42 microsatellite loci to infer the evolutionary relationships of four species in the A. gambiae complex, the two major malaria vectors A. gambiae sensu stricto (A. gambiae s.s.) and A. arabiensis, as well as two minor vectors, A. merus and A. melas. PRINCIPAL
findingsWe identify six taxonomic units, including a clear separation of West and East Africa A. gambiae s.s. S molecular forms. We show that the phylogenetic relationships vary widely between different genomic regions, thus demonstrating the mosaic nature of the genome of these species. The two major malaria vectors are closely related and closer to A. merus than to A. melas at the genome-wide level, which is also true if only autosomes are considered. However, within the Xag inversion region of the X chromosome, the M and two S molecular forms are most similar to A. merus. Near the X centromere, outside the Xag region, the two S forms are highly dissimilar to the other taxa. Furthermore, our data suggest that the centromeric region of chromosome 3 is a strong discriminator between the major and minor malaria vectors.
conclusionsAlthough further studies are needed to elucidate the basis of the phylogenetic variation among the different regions of the genome, the preponderance of sympatric admixtures among taxa strongly favor introgression of different genomic regions between species, rather than lineage sorting of ancestral polymorphism, as a possible mechanism.
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