ArticlePloS one2007
Multiple origins of knockdown resistance mutations in the Afrotropical mosquito vector Anopheles gambiae.
Article in PloS one, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
75 citing papers in PubMed, 124 citations in OpenAlex.
- The status of insecticide resistance of Anopheles coluzzii on the islands of São Tomé and Príncipe, after 20 years of malaria vector control.Malaria journal · 2024Article
- Article
- Molecular diversity of genes related to biological rhythms (period and timeless) and insecticide resistance (Na V and ace-1) in Anopheles darlingi.Memorias do Instituto Oswaldo Cruz · 2023Article
- Countrywide insecticide resistance monitoring and first report of the presence of the L1014S knock down resistance in Niger, West Africa.Malaria journal · 2022Article
- Molecular Drivers of Multiple and Elevated Resistance to Insecticides in a Population of the Malaria VectorGenes · 2022Article
- Spatial heterogeneity of knockdown resistance mutations in the dengue vector Aedes albopictus in Guangzhou, China.Parasites & vectors · 2022Article
- Detection and population genetic analysis of kdr L1014F variant in eastern Ethiopian Anopheles stephensi.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2022Article
- Sympatric Populations of theInsects · 2022Article
- Geographical distribution and origin of acetylcholinesterase mutations conferring acaricide resistance in Tetranychus urticae populations from Turkey.Experimental & applied acarology · 2022Article
- Evolution of the Pyrethroids Target-Site Resistance Mechanisms in Senegal: Early Stage of theGenes · 2021Article
- The genetic architecture of target-site resistance to pyrethroid insecticides in the African malaria vectors Anopheles gambiae and Anopheles coluzzii.Molecular ecology · 2021Article
- Article
- Insecticide Resistance Profiling ofGenes · 2020Article
- Tracing temporal and geographic distribution of resistance to pyrethroids in the arboviral vector Aedes albopictus.PLoS neglected tropical diseases · 2020Article
- Evolution of kdr haplotypes in worldwide populations of Aedes aegypti: Independent origins of the F1534C kdr mutation.PLoS neglected tropical diseases · 2020Article
- High insecticide resistance in the major malaria vector Anopheles coluzzii in Chad Republic.Infectious diseases of poverty · 2019Article
- First detection of the kdr mutation (L1014F) in the plague vector Xenopsylla cheopis (Siphonaptera: Pulicidae).Parasites & vectors · 2019Article
- Insecticide resistance mechanisms with novel 'kdr' type gene mutations in the tropical bed bug Cimex hemipterus.Parasites & vectors · 2019Article
- A combination of metabolic resistance and high frequency of the 1014F kdr mutation is driving pyrethroid resistance in Anopheles coluzzii population from Guinea savanna of Cameroon.Parasites & vectors · 2019Article
- High Plasmodium infection and multiple insecticide resistance in a major malaria vector Anopheles coluzzii from Sahel of Niger Republic.Malaria journal · 2019Article
15 more citing papers are in PubMed but not listed here.
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Authors and funding
13 authors at 8 institutions in 8 countries.
Funding
Abstract
How often insecticide resistance mutations arise in natural insect populations is a fundamental question for understanding the evolution of resistance and also for modeling its spread. Moreover, the development of resistance is regarded as a favored model to study the molecular evolution of adaptive traits. In the malaria vector Anopheles gambiae two point mutations (L1014F and L1014S) in the voltage-gated sodium channel gene, that confer knockdown resistance (kdr) to DDT and pyrethroid insecticides, have been described. In order to determine whether resistance alleles result from single or multiple mutation events, genotyping of the kdr locus and partial sequencing of the upstream intron-1 was performed on a total of 288 A. gambiae S-form collected from 28 localities in 15 countries. Knockdown resistance alleles were found to be widespread in West Africa with co-occurrence of both 1014S and 1014F in West-Central localities. Differences in intron-1 haplotype composition suggest that kdr alleles may have arisen from at least four independent mutation events. Neutrality tests provided evidence for a selective sweep acting on this genomic region, particularly in West Africa. The frequency and distribution of these kdr haplotypes varied geographically, being influenced by an interplay between different mutational occurrences, gene flow and local selection. This has important practical implications for the management and sustainability of malaria vector control programs.
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