ArticlePloS one2007
An obligatory role of mind bomb-1 in notch signaling of mammalian development.
Article in PloS one, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
72 citing papers in PubMed, 120 citations in OpenAlex.
- Genome-Wide Association Study of Rib Number and Total Thoracolumbar Vertebrae Number in a Jishen Black Pig Population.Veterinary sciences · 2026Article
- Engineering synthetic agonists for targeted activation of Notch signaling.Nature chemical biology · 2026Article
- Review
- Neuralized-like proteins differentially activate Notch ligands.EMBO reports · 2025Article
- Structural requirements for activity of Mind bomb1 in Notch signaling.Structure (London, England : 1993) · 2024Article
- Structural Requirements for Activity of Mind bomb1 in Notch Signaling.bioRxiv : the preprint server for biology · 2024Article
- MIB2 promotes the progression of non-small cell lung cancer by regulating cell cycle control pathways.Genes & genomics · 2023Article
- Human Neuralized is a novel tumour suppressor targeting Wnt/β-catenin signalling in colon cancer.EMBO reports · 2023Article
- Comprehensive bioinformatic analysis of mind bomb 1 gene in stomach adenocarcinoma.World journal of gastrointestinal oncology · 2023Article
- Article
- Article
- Biophysics of Notch Signaling.Annual review of biophysics · 2021Review
- Maintenance of type 2 glycolytic myofibers with age by Mib1-Actn3 axis.Nature communications · 2021Article
- MIND bomb 2 prevents RIPK1 kinase activity-dependent and -independent apoptosis through ubiquitylation of cFLIPCommunications biology · 2021Article
- Loss of Adam10 Disrupts Ion Transport in Immortalized Kidney Collecting Duct Cells.Function (Oxford, England) · 2021Article
- Decoding the PTM-switchboard of Notch.Biochimica et biophysica acta. Molecular cell research · 2019Review
- Review
- The E3 ubiquitin ligase MIB2 enhances inflammation by degrading the deubiquitinating enzyme CYLD.The Journal of biological chemistry · 2019Article
- MIB1 mutations reduce Notch signaling activation and contribute to congenital heart disease.Clinical science (London, England : 1979) · 2018Article
- Ectopic expression of E3 ubiquitin-protein ligase 2 in glioma and enhances resistance to apoptosis through activating nuclear factor κ-light-chain-enhancer of B cells.Oncology letters · 2018Article
12 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe Notch signaling pathway is an evolutionarily conserved intercellular signaling module essential for cell fate specification that requires endocytosis of Notch ligands. Structurally distinct E3 ubiquitin ligases, Neuralized (Neur) and Mind bomb (Mib), cooperatively regulate the endocytosis of Notch ligands in Drosophila. However, the respective roles of the mammalian E3 ubiquitin ligases, Neur1, Neur2, Mib1, and Mib2, in mammalian development are poorly understood. METHODOLOGY/PRINCIPAL
findingsThrough extensive use of mammalian genetics, here we show that Neur1 and Neur2 double mutants and Mib2(-/-) mice were viable and grossly normal. In contrast, conditional inactivation of Mib1 in various tissues revealed the representative Notch phenotypes: defects of arterial specification as deltalike4 mutants, abnormal cerebellum and skin development as jagged1 conditional mutants, and syndactylism as jagged2 mutants. CONCLUSIONS/SIGNIFICANCE: Our data provide the first evidence that Mib1 is essential for Jagged as well as Deltalike ligand-mediated Notch signaling in mammalian development, while Neur1, Neur2, and Mib2 are dispensable.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.