ReviewCurrent opinion in hematology2008
Basophils and type 2 immunity.
Review in Current opinion in hematology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 81 citations in OpenAlex.
- Mass Cytometry Reveals Cell Type-specific Immune Remodeling in Placentas of Women with Chronic Hepatitis B Infection.Journal of clinical and translational hepatology · 2026Article
- Article
- Basophils in atopic dermatitis: Immunologic roles and clinical implications.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2026Review
- From skin to lung: basophil-mediated spread of allergic diseases.Frontiers in immunology · 2026Review
- Big data- and machine learning-based analysis of a global pharmacovigilance database enables the discovery of sex-specific differences in the safety profile of dual IL4/IL13 blockade.Frontiers in pharmacology · 2023Article
- Diagnostic value of white blood cell parameters for COVID-19: Is there a role for HFLC and IG?International journal of laboratory hematology · 2022Article
- Article
- Paradigm Shifts in Mast Cell and Basophil Biology and Function: An Emerging View of Immune Regulation in Health and Disease.Methods in molecular biology (Clifton, N.J.) · 2020Review
- Difference in Biomarkers Between COVID-19 Patients and Other Pulmonary Infection Patients.Infection and drug resistance · 2020Article
- Human Mucosal Mast Cells Capture HIV-1 and Mediate Viral trans-Infection of CD4+ T Cells.Journal of virology · 2015Article
- Human Blood-Circulating Basophils Capture HIV-1 and Mediate Viral trans-Infection of CD4+ T Cells.Journal of virology · 2015Article
- Article
- Cytokine-induced cytokine production by conventional and innate lymphoid cells.Trends in immunology · 2012Review
- Chronic helminth infection reduces basophil responsiveness in an IL-10-dependent manner.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- State-of-the-art review about basophil research in immunology and allergy: is the time right to treat these cells with the respect they deserve?Blood transfusion = Trasfusione del sangue · 2012Review
- Potential role of histamine releasing factor (HRF) as a therapeutic target for treating asthma and allergy.Journal of asthma and allergy · 2012Article
- Murine but not human basophil undergoes cell-specific proteolysis of a major endoplasmic reticulum chaperone.PloS one · 2012Article
- Differential role of hypoxia-inducible factor 1 alpha in toll-like receptor-mediated and allergic inflammatory reactions.The World Allergy Organization journal · 2010Article
- Effect of Maternal HIV-1 Status and Antiretroviral Drugs on Haematological Profiles of South African Infants in Early Life.The open AIDS journal · 2010Article
- Programming dendritic cells to induce T(H)2 and tolerogenic responses.Nature immunology · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
purpose of reviewMechanisms involved in the development of in-vivo type 2 immunity are poorly defined. Basophils are potent IL-4-producing cells and may contribute to the process of polarizing immune responses. RECENT
findingsAlthough basophils represent fewer than 0.5% of blood leukocytes, their frequency dramatically increases under certain circumstances, particularly Th2-related responses including parasitic infection and allergic inflammation. Recent studies proposed the hypothesis that basophils could contribute to the development of type 2 immunity by providing initial IL-4 important in T cell polarization and by recruiting other effector cells such as eosinophils or neutrophils. Multiple stimuli of IgE-dependent and IgE-independent pathways that lead to release of cytokines and mediators from activated basophils have been identified. In addition, progenitors that differentiate into mature basophils have recently been identified. SUMMARY: The current review revisits basophils with the goal of providing insights into understanding unappreciated roles of basophils in vivo.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.