ArticleNeuroepidemiology2007
Gait variability is associated with subclinical brain vascular abnormalities in high-functioning older adults.
Article in Neuroepidemiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04439591 (Group-based Brain-computer Interface), which is not on this map. Cited by 93 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Group-based Brain-computer Interface (BCI) Cognitive Training in Healthy Older Adults: An Evaluation of Programme Implementation and Effectiveness in Neighborhood Community Centers
Who cites it
93 citing papers in PubMed, 6 syntheses or guidelines pooled it, 187 citations in OpenAlex.
- Gait and falls in cerebral small vessel disease: a systematic review and meta-analysis.Age and ageing · 2023Pooled it
- Gait in cerebral small vessel disease, pre-dementia, and dementia: A systematic review.International journal of stroke : official journal of the International Stroke Society · 2023Pooled it
- The brain map of gait variability in aging, cognitive impairment and dementia-A systematic review.Neuroscience and biobehavioral reviews · 2017Pooled it
- Poor Gait Performance and Prediction of Dementia: Results From a Meta-Analysis.Journal of the American Medical Directors Association · 2016Pooled it
- Pooled it
- Contribution of brain imaging to the understanding of gait disorders in Alzheimer's disease: a systematic review.American journal of Alzheimer's disease and other dementias · 2012Pooled it
- Trial
- Group-based exercise and cognitive-physical training in older adults with self-reported cognitive complaints: The Multiple-Modality, Mind-Motor (M4) study protocol.BMC geriatrics · 2016Trial
- Higher step length variability indicates lower gray matter integrity of selected regions in older adults.Gait & posture · 2014Trial
- White matter hyperintensities, exercise, and improvement in gait speed: does type of gait rehabilitation matter?Journal of the American Geriatrics Society · 2013Trial
- Functional neural correlates of reduced physiological falls risk.Behavioral and brain functions : BBF · 2011Trial
- Article
- Age-related and dual task-induced gait alterations and asymmetry: optimizing the Semmelweis Study gait assessment protocol.GeroScience · 2025Article
- From Dual Decline to Clinical Consequences: Mechanistic Pathways and Health Outcomes of Motoric Cognitive Risk Syndrome.Aging and disease · 2025Review
- Personalized versus fixed tactile cueing in Parkinson's disease: Protocol for a randomized controlled trial on gait automaticity.PloS one · 2025Article
- Article
- NONAN GaitPrint: An IMU gait database of healthy young adults.Scientific data · 2023Article
- Faster Walking Speeds Require Greater Activity from the Primary Motor Cortex in Older Adults Compared to Younger Adults.Sensors (Basel, Switzerland) · 2023Article
- IoT-Enabled Gait Assessment: The Next Step for Habitual Monitoring.Sensors (Basel, Switzerland) · 2023Review
- Reliability and Validity of Inertial Sensor Assisted Reaction Time Measurement Tools among Healthy Young Adults.Sensors (Basel, Switzerland) · 2022Article
33 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundGait variability is an index of how much gait parameters, such as step length, change from one step to the next. Gait variability increases with age and in individuals affected by cortical and subcortical neurodegenerative conditions, and it is associated with falls and incident mobility disability. The brain anatomical correlates of gait variability have not been studied in high-functioning community-dwelling older adults.
methodsGait variability and brain MRIs were assessed in a cohort of 331 men and women (mean age = 78.3 years) free from stroke, dementia or Parkinson's disease. Gait variability was computed for spatial parameters (step length and step width) and for temporal parameters (stance time). Subclinical brain vascular abnormalities were measured on brain MRIs as infarcts and white matter hyperintensities.
resultsGreater variability of step length was associated with greater prevalence of infarcts, including infarcts in the basal ganglia, and with greater white matter hyperintensities severity, independent of age, gender, cognitive function and cardiovascular disease. Weaker associations were found between the other variability measures and the MRI measures.
conclusionIn this group of older adults free from neurodegenerative diseases, a greater variability of step length was associated with greater burden of subclinical brain vascular abnormalities as defined by MRI.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.