ArticleProceedings of the National Academy of Sciences of the United States of America2007
Genetic variation in the cysteine biosynthesis pathway causes sensitivity to pharmacological compounds.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 55 citations in OpenAlex.
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- A Proteomic Landscape of Candida albicans in the Stepwise Evolution to Fluconazole Resistance.Antimicrobial agents and chemotherapy · 2022Article
- Independent Mechanisms for Acquired Salt Tolerance versus Growth Resumption Induced by Mild Ethanol Pretreatment inmSphere · 2018Article
- Linkage mapping of yeast cross protection connects gene expression variation to a higher-order organismal trait.PLoS genetics · 2018Article
- Natural Variation inG3 (Bethesda, Md.) · 2018Article
- Identification of Nitrogen Consumption Genetic Variants in Yeast Through QTL Mapping and Bulk Segregant RNA-Seq Analyses.G3 (Bethesda, Md.) · 2017Article
- The genetic architecture of low-temperature adaptation in the wine yeast Saccharomyces cerevisiae.BMC genomics · 2017Article
- Inhibitors of amino acids biosynthesis as antifungal agents.Amino acids · 2015Review
- Genetic architecture of ethanol-responsive transcriptome variation in Saccharomyces cerevisiae strains.Genetics · 2014Article
- A genetic approach of wine yeast fermentation capacity in nitrogen-starvation reveals the key role of nitrogen signaling.BMC genomics · 2014Article
- Dynamic large-scale chromosomal rearrangements fuel rapid adaptation in yeast populations.PLoS genetics · 2013Article
- Allele-specific behavior of molecular networks: understanding small-molecule drug response in yeast.PloS one · 2013Article
- A noncomplementation screen for quantitative trait alleles in saccharomyces cerevisiae.G3 (Bethesda, Md.) · 2012Article
- Prevalence of MTHFR C677T and MS A2756G polymorphisms in major depressive disorder, and their impact on response to fluoxetine treatment.CNS spectrums · 2012Article
- Divergence of the yeast transcription factor FZF1 affects sulfite resistance.PLoS genetics · 2012Article
- Genetic architecture of highly complex chemical resistance traits across four yeast strains.PLoS genetics · 2012Article
- Advances in quantitative trait analysis in yeast.PLoS genetics · 2012Review
- What does it take to synergistically combine sub-potent natural products into drug-level potent combinations?PloS one · 2012Article
- From sequence to function: Insights from natural variation in budding yeasts.Biochimica et biophysica acta · 2011Review
- Deciphering the molecular basis of wine yeast fermentation traits using a combined genetic and genomic approach.G3 (Bethesda, Md.) · 2011Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Complex traits are the product of multiple genes with effects that depend on both the genetic and environmental background. Although this complexity makes a comprehensive genetic analysis difficult, identification of even a single gene provides insight into the biochemical and/or signaling pathway underlying a trait. However, it is unknown whether multiple pathways, and consequently multiple genes, must be identified to adequately understand a trait's molecular basis. Using crosses between three natural isolates of Saccharomyces cerevisiae, we mapped sensitivity to a number of pharmacologically active compounds to a single nonsynonymous polymorphism in cystathione-beta-synthase (CYS4), which is required for the first committed step in the cysteine biosynthesis pathway. Drug sensitivity is mediated by a deficiency in cysteine and consequently glutathione production, because drug sensitivity is abrogated by cysteine or glutathione supplementation. Within a diverse panel of 60 natural yeast isolates, the drug-sensitive CYS4 allele is rare, and glutathione supplementation failed to alleviate drug-dependent growth defects in two other drug-sensitive strains. These results implicate the cysteine/glutathione biosynthesis pathway as a significant, but not the sole contributor to pharmacological variation in yeast.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.