ArticleProceedings of the National Academy of Sciences of the United States of America2007
The P2 capsid protein of the nonenveloped rice dwarf phytoreovirus induces membrane fusion in insect host cells.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 41 citations in OpenAlex.
- Article
- Role of Plant Virus Movement Proteins in Suppression of Host RNAi Defense.International journal of molecular sciences · 2023Review
- Exosomes mediate horizontal transmission of viral pathogens from insect vectors to plant phloem.eLife · 2021Article
- Mechanisms of Cell Entry by dsRNA Viruses: Insights for Efficient Delivery of dsRNA and Tools for Improved RNAi-Based Pest Control.Frontiers in physiology · 2021Review
- Auxin response factors (ARFs) differentially regulate rice antiviral immune response against rice dwarf virus.PLoS pathogens · 2020Article
- Rice Dwarf Virus Small RNA Profiles in Rice and Leafhopper Reveal Distinct Patterns in Cross-Kingdom Hosts.Viruses · 2019Article
- A viral protein promotes host SAMS1 activity and ethylene production for the benefit of virus infection.eLife · 2017Article
- Plant Virus-Insect Vector Interactions: Current and Potential Future Research Directions.Viruses · 2016Review
- Electron microscopic imaging revealed the flexible filamentous structure of the cell attachment protein P2 of Rice dwarf virus located around the icosahedral 5-fold axes.Journal of biochemistry · 2016Article
- Nonstructural protein Pns4 of rice dwarf virus is essential for viral infection in its insect vector.Virology journal · 2015Article
- OsRDR6 plays role in host defense against double-stranded RNA virus, Rice Dwarf Phytoreovirus.Scientific reports · 2015Article
- Facilitation of rice stripe virus accumulation in the insect vector by Himetobi P virus VP1.Viruses · 2015Article
- Evolution of eukaryotic single-stranded DNA viruses of the Bidnaviridae family from genes of four other groups of widely different viruses.Scientific reports · 2014Article
- Life cycle of phytoreoviruses visualized by electron microscopy and tomography.Frontiers in microbiology · 2013Review
- Surface display of rice stripe virus NSvc2 and analysis of its membrane fusion activity.Virologica Sinica · 2012Article
- Tubular structure induced by a plant virus facilitates viral spread in its vector insect.PLoS pathogens · 2012Article
- Rice dwarf viruses with dysfunctional genomes generated in plants are filtered out in vector insects: implications for the origin of the virus.Journal of virology · 2011Article
- Multiple functions of Rice dwarf phytoreovirus Pns10 in suppressing systemic RNA silencing.Journal of virology · 2010Article
- Insect cell culture and applications to research and pest management.In vitro cellular & developmental biology. AnimalReview
Corrections and comments
- Erratum issuedWei, Taiyuan [corrected to Wei, Taiyun]
Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
Abstract
Insect transmission is an essential process of infection for numerous plant and animal viruses. How an insect-transmissible plant virus enters an insect cell to initiate the infection cycle is poorly understood, especially for nonenveloped plant and animal viruses. The capsid protein P2 of rice dwarf virus (RDV), which is nonenveloped, is necessary for insect transmission. Here, we present evidence that P2 shares structural features with membrane-fusogenic proteins encoded by enveloped animal viruses. When RDV P2 was ectopically expressed and displayed on the surface of insect Spodoptera frugiperda cells, it induced membrane fusion characterized by syncytium formation at low pH. Mutational analyses identified the N-terminal and a heptad repeat as being critical for the membrane fusion-inducing activity. These results are corroborated with results from RDV-infected cells of the insect vector leafhopper. We propose that the RDV P2-induced membrane fusion plays a critical role in viral entry into insect cells. Our report that a plant viral protein can induce membrane fusion has broad significance in studying the mechanisms of virus entry into insect cells and insect transmission of nonenveloped plant and animal viruses.
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