ArticleMolecular cell2007
Structure of the Pho85-Pho80 CDK-cyclin complex of the phosphate-responsive signal transduction pathway.
Article in Molecular cell, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 59 citations in OpenAlex.
- Evolutionary turnover of key amino acids explains conservation of function without conservation of sequence in transcriptional activation domains.PLoS genetics · 2026Article
- Genomic Discovery and Structure-Activity Exploration of a Novel Family of Enzyme-Activated Covalent Cyclin-Dependent Kinase Inhibitors.Journal of medicinal chemistry · 2024Article
- Inositol pyrophosphate dynamics reveals control of the yeast phosphate starvation program through 1,5-IPeLife · 2023Article
- TheFrontiers in microbiology · 2022Article
- A transcriptional activator fromFrontiers in microbiology · 2022Article
- Structural basis for CDK7 activation by MAT1 and Cyclin H.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- IPmBio · 2020Article
- A precisely positioned MED12 activation helix stimulates CDK8 kinase activity.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Identity and functions of inorganic and inositol polyphosphates in plants.The New phytologist · 2020Review
- Aggregate Filamentous Growth Responses in Yeast.mSphere · 2019Article
- Article
- Homing in: Mechanisms of Substrate Targeting by Protein Kinases.Trends in biochemical sciences · 2018Review
- Structural basis of divergent cyclin-dependent kinase activation by Spy1/RINGO proteins.The EMBO journal · 2017Article
- Structure and inhibitor specificity of the PCTAIRE-family kinase CDK16.The Biochemical journal · 2017Article
- Core regulatory components of the PHO pathway are conserved in the methylotrophic yeast Hansenula polymorpha.Current genetics · 2016Article
- Nutrient sensing and signaling in the yeast Saccharomyces cerevisiae.FEMS microbiology reviews · 2014Review
- New structural insights into phosphorylation-free mechanism for full cyclin-dependent kinase (CDK)-cyclin activity and substrate recognition.The Journal of biological chemistry · 2013Article
- Phosphate-activated cyclin-dependent kinase stabilizes G1 cyclin to trigger cell cycle entry.Molecular and cellular biology · 2013Article
- Defective in mitotic arrest 1 (Dma1) ubiquitin ligase controls G1 cyclin degradation.The Journal of biological chemistry · 2013Article
- Analysis of substrate specificity and cyclin Y binding of PCTAIRE-1 kinase.Cellular signalling · 2012Article
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
The ability to sense and respond appropriately to environmental changes is a primary requirement of all living organisms. In response to phosphate limitation, Saccharomyces cerevisiae induces transcription of a set of genes involved in the regulation of phosphate acquisition from the ambient environment. A signal transduction pathway (the PHO pathway) mediates this response, with Pho85-Pho80 playing a vital role. Here we report the X-ray structure of Pho85-Pho80, a prototypic structure of a CDK-cyclin complex functioning in transcriptional regulation in response to environmental changes. The structure revealed a specific salt link between a Pho85 arginine and a Pho80 aspartate that makes phosphorylation of the Pho85 activation loop dispensable and that maintains a Pho80 loop conformation for possible substrate recognition. It further showed two sites on the Pho80 cyclin for high-affinity binding of the transcription factor substrate (Pho4) and the CDK inhibitor (Pho81) that are markedly distant to each other and the active site.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.