Evidence map›Paper›PMID 18042294›Full record

ArticleBiomedical engineering online2007

Fabrication and in vitro deployment of a laser-activated shape memory polymer vascular stent.

Géraldine M Baer, Ward Small, Thomas S Wilson, William J Benett, Dennis L Matthews, Jonathan Hartman, Duncan J Maitland

Open access · goldAbstract readEvaluation Study
In one paragraph

Article in Biomedical engineering online, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
4.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 155 citations in OpenAlex.

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  17. Shape transformable bifurcated stents.Scientific reports · 2018
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Géraldine M BaerDepartment of Biomedical Engineering, University of California, Davis, California 95616 USA. gmbaer@ucdavis.edu
Ward Small
Thomas S Wilson
William J Benett
Dennis L Matthews
Jonathan Hartman
Duncan J Maitland
Lawrence Livermore National Laboratory · USUniversity of California, Davis · USKaiser Permanente Sacramento Medical Center · US

Funding

Shape Memory Polymer Devices for Treating StrokeR01EB000462 · NIBIB · UNIVERSITY OF CALIF-LAWRNC LVRMR NAT LAB · PI MAITLAND, DUNCAN J · 2002 to 2012
$12.5M
NIBIB NIH HHS R01 EB000462NIBIB NIH HHS R01EB000462
6 · The paper itself

Abstract

backgroundVascular stents are small tubular scaffolds used in the treatment of arterial stenosis (narrowing of the vessel). Most vascular stents are metallic and are deployed either by balloon expansion or by self-expansion. A shape memory polymer (SMP) stent may enhance flexibility, compliance, and drug elution compared to its current metallic counterparts. The purpose of this study was to describe the fabrication of a laser-activated SMP stent and demonstrate photothermal expansion of the stent in an in vitro artery model.

methodsA novel SMP stent was fabricated from thermoplastic polyurethane. A solid SMP tube formed by dip coating a stainless steel pin was laser-etched to create the mesh pattern of the finished stent. The stent was crimped over a fiber-optic cylindrical light diffuser coupled to an infrared diode laser. Photothermal actuation of the stent was performed in a water-filled mock artery.

resultsAt a physiological flow rate, the stent did not fully expand at the maximum laser power (8.6 W) due to convective cooling. However, under zero flow, simulating the technique of endovascular flow occlusion, complete laser actuation was achieved in the mock artery at a laser power of ~8 W.

conclusionWe have shown the design and fabrication of an SMP stent and a means of light delivery for photothermal actuation. Though further studies are required to optimize the device and assess thermal tissue damage, photothermal actuation of the SMP stent was demonstrated.

Indexed as

Blood Vessel ProsthesisLasersStentsCoated Materials, BiocompatibleEquipment DesignEquipment Failure AnalysisMolecular ConformationPolymersStainless SteelCoated Materials, BiocompatiblePolymersStainless Steel

Identifiers

PMID18042294
PMCPMC2211751
OpenAlexW2161662294

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.