ArticleHuman brain mapping2009
STN-stimulation in Parkinson's disease restores striatal inhibition of thalamocortical projection.
Article in Human brain mapping, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effective network of deep brain stimulation of subthalamic nucleus with bimodal positron emission tomography/functional magnetic resonance imaging in Parkinson's disease.CNS neuroscience & therapeutics · 2018Pooled it
- Deep brain stimulation reveals emotional impact processing in ventromedial prefrontal cortex.PloS one · 2009Trial
- Brain Imaging Changes Following Deep Brain Stimulation Patients with Parkinson's Disease: A Literature Review.Movement disorders clinical practice · 2026Review
- Molecular glucose imaging reveals functional brain reconfiguration by subthalamic deep brain stimulation in Parkinsonian rats.Translational neurodegeneration · 2025Article
- Striatal and cerebellar interactions during reward-based motor performance.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Striatal and cerebellar interactions during reward-based motor performance.bioRxiv : the preprint server for biology · 2025Article
- A framework for translational therapy development in deep brain stimulation.NPJ Parkinson's disease · 2024Review
- Does Impaired Plantar Cutaneous Vibration Perception Contribute to Axial Motor Symptoms in Parkinson's Disease? Effects of Medication and Subthalamic Nucleus Deep Brain Stimulation.Brain sciences · 2023Article
- Dopamine Synthesis Capacity and GABA and Glutamate Levels Separate Antipsychotic-Naïve Patients With First-Episode Psychosis From Healthy Control Subjects in a Multimodal Prediction Model.Biological psychiatry global open science · 2023Article
- The role of neuroimaging in Parkinson's disease.Journal of neurochemistry · 2021Review
- The Pause-then-Cancel model of human action-stopping: Theoretical considerations and empirical evidence.Neuroscience and biobehavioral reviews · 2021Review
- Deep brain stimulation of the internal globus pallidus does not affect the limbic circuit in patients with Parkinson's disease: a PET study.Journal of neurology · 2021Article
- RF heating of deep brain stimulation implants in open-bore vertical MRI systems: A simulation study with realistic device configurations.Magnetic resonance in medicine · 2020Article
- Article
- Effects of subthalamic deep brain stimulation on striatal metabolic connectivity in a rat hemiparkinsonian model.Disease models & mechanisms · 2019Article
- The basal ganglia and the cerebellum: nodes in an integrated network.Nature reviews. Neuroscience · 2018Review
- Deep Brain Stimulation and L-DOPA Therapy: Concepts of Action and Clinical Applications in Parkinson's Disease.Frontiers in neurology · 2018Review
- Levodopa Effect on Basal Ganglia Motor Circuit in Parkinson's Disease.CNS neuroscience & therapeutics · 2017Article
- Network effects of deep brain stimulation.Journal of neurophysiology · 2015Review
- Hippocampal deep brain stimulation reduces glucose utilization in the healthy rat brain.Molecular imaging and biology · 2015Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To test the hypothesis that deep brain stimulation of the subthalamic nucleus (STN) restores the inhibitory output to the striatothalamocortical loop in Parkinson's disease, we obtained functional brain images of blood flow in 10 STN-stimulated patients with Parkinson's disease. Patients were immobile and off antiparkinsonian medication for 12 h. They were scanned with and without bilateral STN-stimulation with a 4-h interval between the two conditions. The order of DBS stimulation (ON or OFF) was randomized. Stimulation significantly raised regional cerebral blood flow (rCBF) bilaterally in the STN and in the left nucleus lentiformis. Conversely, flow declined in the left supplementary motor area (BA 6), ventrolateral nucleus of the left thalamus, and right cerebellum. Activation of the basal ganglia and deactivation of supplementary motor area and thalamus were both correlated with the improvement of motor function. The result is consistent with the explanation that stimulation in resting patients raises output from the STN with activation of the inhibitory basal ganglia output nuclei and subsequent deactivation of the thalamic anteroventral and ventrolateral nuclei and the supplementary motor area.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.