ReviewJournal of neuroscience research2008
Glial ensheathment of peripheral axons in Drosophila.
Review in Journal of neuroscience research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed.
- Review
- Peripheral glia and neurons jointly regulate activity-induced synaptic remodeling at theeLife · 2025Article
- Review
- The function of Scox in glial cells is essential for locomotive ability in Drosophila.Scientific reports · 2021Article
- Glial ensheathment of the somatodendritic compartment regulates sensory neuron structure and activity.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Axonal Ensheathment in the Nervous System of Lamprey: Implications for the Evolution of Myelinating Glia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Different Levels of Expression of the Clock Protein PER and the Glial Marker REPO in Ensheathing and Astrocyte-Like Glia of the Distal Medulla ofFrontiers in physiology · 2018Article
- Coupled circumferential and axial tension driven by actin and myosin influences in vivo axon diameter.Scientific reports · 2017Article
- Molecular Chaperone Calnexin Regulates the Function ofFrontiers in molecular neuroscience · 2017Article
- Mechanism of Axonal Contractility in Embryonic Drosophila Motor Neurons In Vivo.Biophysical journal · 2016Article
- Changes in organelle position and epithelial architecture associated with loss of CrebA.Biology open · 2015Article
- The Drosophila surface glia transcriptome: evolutionary conserved blood-brain barrier processes.Frontiers in neuroscience · 2014Article
- A global in vivo Drosophila RNAi screen identifies a key role of ceramide phosphoethanolamine for glial ensheathment of axons.PLoS genetics · 2013Article
- Microfluidic chips for in vivo imaging of cellular responses to neural injury in Drosophila larvae.PloS one · 2012Article
- Article
- Article
- The peripheral nervous system supports blood cell homing and survival in the Drosophila larva.Development (Cambridge, England) · 2011Article
- Neuronal polarity in Drosophila: sorting out axons and dendrites.Developmental neurobiology · 2011Review
- The curious case of NG2 cells: transient trend or game changer?ASN neuro · 2011Review
- In vivo deletion of immunoglobulin domains 5 and 6 in neurofascin (Nfasc) reveals domain-specific requirements in myelinated axons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The ensheathment of neurons and their axons creates an ion-sensitive microenvironment that allows rapid conduction of nerve impulses. One of the fundamental questions about axonal ensheathment is how insulating glial cells wrap around axons. The mechanisms that underlie insulation of axons in invertebrates and vertebrates are not fully understood. In the present article we address cellular aspects of axonal ensheathment in Drosophila by taking advantage of glial mutants that illustrate a range of phenotypic defects including ensheathment of axons. From the findings of these mutant studies, we summarize that loss of glial cells, defects in glial membrane wrapping, failure of glial migration, and loss of specialized ladderlike septate junctions between ensheathing glial membranes result in axon-glial functional defects. These studies provide a broad perspective on glial ensheathment of axons in Drosophila and key insights into the anatomical and cellular aspects of axonal insulation. Given the powerful genetic approaches available in Drosophila, the axonal ensheathment process can be dissected in great detail to reveal the fundamental principles of ensheathment. These observations will be relevant to understanding the very similar processes in vertebrates, where defects in glial cell functions lead to devastating neurological diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.