ArticleJournal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology2007
Morphine-induced neuroimmunomodulation in murine visceral leishmaniasis: the role(s) of cytokines and nitric oxide.
Article in Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 31 citations in OpenAlex.
- Impact of recently initiated medications on the incidence of urinary tract infections in patients with type 2 diabetes: an observational case-control study.Therapeutic advances in drug safety · 2025Article
- Synergistic Anti-Leishmanial Activities of Morphine and Imiquimod onJournal of arthropod-borne diseases · 2021Article
- The Role of Opioid Receptors in Immune System Function.Frontiers in immunology · 2019Review
- Effect of Topical Morphine on Cutaneous Leishmaniasis in an Animal Model: A Preliminary Report.Iranian Red Crescent medical journal · 2016Article
- A prospective cohort study of cutaneous leishmaniasis risk and opium addiction in south eastern Iran.PloS one · 2014Article
- Role of the mu-opioid receptor in opioid modulation of immune function.Amino acids · 2013Review
- Regulation of mu opioid receptor expression in developing T cells.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2012Article
- Morphine, but not trauma, sensitizes to systemic Acinetobacter baumannii infection.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2011Article
- Opioid drug abuse and modulation of immune function: consequences in the susceptibility to opportunistic infections.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2011Review
- A screen against Leishmania intracellular amastigotes: comparison to a promastigote screen and identification of a host cell-specific hit.PLoS neglected tropical diseases · 2011Article
- Potentiating effect of morphine on oral Salmonella enterica serovar Typhimurium infection is μ-opioid receptor-dependent.Microbial pathogenesis · 2010Article
- Intensive Care Unit-acquired infection as a side effect of sedation.Critical care (London, England) · 2010Review
- Effect of morphine on Mycobacterium smegmatis infection in mice and macrophages.Indian journal of microbiology · 2009Article
- Interactions between morphine and nitric oxide in various organs.Journal of anesthesia · 2009Review
- Evaluation of Morphine with Imiquimod as Opioid Growth Factor Receptor or Nalmefene as Opioid Blocking Drug on Leishmaniasis Caused byIranian journal of parasitologyArticle
- Opioid System Modulates the Immune Function: A Review.Translational perioperative and pain medicineArticle
- Opioids in Cancer Pain Management: A Double-Edged Sword of Relief and Risk.Nigerian medical journal : journal of the Nigeria Medical AssociationReview
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Opioid modulation of host resistance to infectious diseases is well documented; however, not much is known during visceral leishmaniasis (VL). Low doses of morphine, administered subcutaneously in Leishmania donovani-infected BALB/c mice, on days 0 and +15, significantly (p < 0.05) suppressed (1 mg/kg/day) or even sterile-cleared (2 mg/kg/day) the infection; paradoxically, high doses (10 and 30 mg/kg/day) exacerbated the infection. In vitro, low concentration (1 x 10(-9) and 1 x 10(-11) M) morphine treatment of L. donovani-infected mouse peritoneal macrophages (PM), endowed them with significant (p < 0.05) leishmanicidal activity, whereas a high-concentration (1 x 10(-5) M) treatment augmented intramacrophage parasite growth. Naloxone pre-treatment of infected-mice (4 mg/kg x 2) and of infected-PM (1 x 10(-5) M), blocked only the morphine low dose/concentration-induced protective effect. The splenocytes from protected mice and morphine low concentration-treated infected-PM, elaborated significantly (p < 0.05) enhanced levels of interleukin-12, interferon-gamma, tumor necrosis factor-alpha, granulocyte-macrophage colony-stimulating factor and nitrite in the culture medium; a high dose/concentration suppressed their elaboration. Curiously, only morphine high dose/concentration-treated infected mice splenocytes and infected PM, produced significantly (p < 0.05) increased quantity of transforming growth factor-beta1. Aminoguanidine, significantly (p < 0.05) blocked the morphine low dose/concentration-induced protective effect, in vivo and in vitro. This first study demonstrates dose-dependent biphasic modulatory effects of morphine in L. donovani-infected mice and PM, in vitro, apparently via nitric oxide-dependent mechanisms. These results thus demonstrate the implications of opiate abuse on the efficacy assessment of antileishmanial drugs and vaccines, and on the reactivation of latent VL in areas where both drug abuse and VL are rampant.
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