ReviewClinical oral investigations2008
In vitro and in vivo studies on the toxicity of dental resin components: a review.
Review in Clinical oral investigations, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 140 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
140 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Toxicity of resin-matrix composites in a dental clinical setting.Odontology · 2025Pooled it
- Effects of triethylene glycol dimethacrylate and bisphenol A-glycidyl methacrylate on annexin A proteins in human mesangial cells.European journal of oral sciences · 2026Article
- Assessment of Monomer Release From Resin Composites Following the Use of Various Modeling Liquids.Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.] · 2026Article
- In Vitro Cytotoxicity of Three Dimethacrylate-Based Photopolymer Resins for 3D-Printed Dental Restorations: A Qualitative Morphological Screening on Human Fibroblasts.Journal of functional biomaterials · 2026Article
- Polymerization Kinetics of Conventional vs. Fiber-Reinforced Composites Using Rapid High-Intensity Photo-Activation.Polymers · 2026Article
- Mitigating Monomer Leaching and Resin-Related Hypersensitivity in Removable Orthodontics Through Bio-Inspired Surface Modifications: A Narrative Review.Biomimetics (Basel, Switzerland) · 2026Review
- Novel Metformin-Containing Antibacterial Composite for Root Caries Restorations.Materials (Basel, Switzerland) · 2026Article
- Dose- and time-dependent cytotoxic responses of contemporary glass ionomer cements: an in vitro study.BMC oral health · 2026Article
- Calcium Silicate-Based Cements for Vital Pulp Therapy: Integrated Assessment of Radiopacity, Elemental Composition, and 24-h Pulp Cell Responses.Biomimetics (Basel, Switzerland) · 2026Article
- Effect of Ceramic Thickness and Adhesive Light Curing on Bond Strength of Resin Cements to Enamel.European journal of dentistry · 2026Article
- Validation of a fast LC-MS/MS method for the analysis of bisphenol A (BPA) and urethane dimethacrylate (UDMA) in eluates of dental polymer-based materials.Scientific reports · 2026Article
- Evaluation of the total antioxidant capacity and cytotoxicity of single shade universal resin composites.BMC oral health · 2025Article
- Activation of Inflammatory and Apoptosis Pathways on Human Gingival Fibroblasts Exposed to Dental Resin Composites.Polymers · 2025Article
- Release of monomers in patient saliva following bonding of orthodontic brackets.European journal of orthodontics · 2025Article
- Cytotoxicity of Bulk-Fill Composites on Stem Cells from Human Exfoliated Deciduous Teeth-An In Vitro Study.Materials (Basel, Switzerland) · 2025Article
- Multifunctional resin-matrix ceramic: synergistic mechanical-biological optimization and novel strategies for translational research.RSC advances · 2025Review
- The effect of hydrogen peroxide and subsequent resveratrol application to CAD-CAM blocks on the cell viability of fibroblasts.Odontology · 2025Article
- Article
- Clinical performance of different composite materials in class II cavities bonded with universal adhesives.Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.] · 2025Article
- Polyhydroxybutyrate as a Novel Biopolymer for Dental Restorative Materials: Biological and Morphological Analysis.Polymers · 2025Article
80 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In vitro and in vivo studies have clearly identified that some components of restorative composite resins, adhesives, and resin-modified glass ionomer cements are toxic. The mechanisms of cytotoxicity are related firstly to the short-term release of free monomers occurring during the monomer-polymer conversion. Secondly, long-term release of leachable substances is generated by erosion and degradation over time. In addition, ion release and proliferation of bacteria located at the interface between the restorative material and dental tissues are also implicated in the tissue response. Molecular mechanisms involve glutathione depletion and reactive oxygen species (ROS) production as key factors leading to pulp or gingival cell apoptosis. Experimental animal approaches substantiate the occurrence of allergic reactions. There is a large gap between the results published by research laboratories and clinical reports.
Indexed as
Identifiers
18040729What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.