ArticleGenetics2007
Phylogenetic footprinting analysis in the upstream regulatory regions of the Drosophila enhancer of split genes.
Article in Genetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Notch Signaling in Insect Development: A Simple Pathway with Diverse Functions.International journal of molecular sciences · 2023Review
- Article
- Origin and evolution of the enhancer of split complex.BMC genomics · 2015Article
- The Drosophila enhancer of split gene complex: architecture and coordinate regulation by notch, cohesin, and polycomb group proteins.G3 (Bethesda, Md.) · 2013Article
- CBS: an open platform that integrates predictive methods and epigenetics information to characterize conserved regulatory features in multiple Drosophila genomes.BMC genomics · 2012Article
- The effects of methylmercury on Notch signaling during embryonic neural development in Drosophila melanogaster.Toxicology in vitro : an international journal published in association with BIBRA · 2012Article
- The Enhancer of split complex arose prior to the diversification of schizophoran flies and is strongly conserved between Drosophila and stalk-eyed flies (Diopsidae).BMC evolutionary biology · 2011Article
- Article
- Evolution of a genomic regulatory domain: the role of gene co-option and gene duplication in the Enhancer of split complex.Genome research · 2010Article
- Regulation of the Drosophila Enhancer of split and invected-engrailed gene complexes by sister chromatid cohesion proteins.PloS one · 2009Article
- The evolution of hierarchical gene regulatory networks.Nature reviews. Genetics · 2009Review
- Sequence conservation and combinatorial complexity of Drosophila neural precursor cell enhancers.BMC genomics · 2008Article
- The tiny Hairless protein from Apis mellifera: a potent antagonist of Notch signaling in Drosophila melanogaster.BMC evolutionary biology · 2008Article
- Discovery of functional elements in 12 Drosophila genomes using evolutionary signatures.Nature · 2007Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
During Drosophila development Suppressor of Hairless [Su(H)]-dependent Notch activation upregulates transcription of the Enhancer of split-Complex [E(spl)-C] genes. Drosophila melanogaster E(spl) genes share common transcription regulators including binding sites for Su(H), proneural, and E(spl) basic-helix-loop-helix (bHLH) proteins. However, the expression patterns of E(spl) genes during development suggest that additional factors are involved. To better understand regulators responsible for these expression patterns, recently available sequence and annotation data for multiple Drosophila genomes were used to compare the E(spl) upstream regulatory regions from more than nine Drosophila species. The mgamma and mbeta regulatory regions are the most conserved of the bHLH genes. Fine analysis of Su(H) sites showed that high-affinity Su(H) paired sites and the Su(H) paired site plus proneural site (SPS + A) architecture are completely conserved in a subset of Drosophila E(spl) genes. The SPS + A module is also present in the upstream regulatory regions of the more ancient mosquito and honeybee E(spl) bHLH genes. Additional transcription factor binding sites were identified upstream of the E(spl) genes and compared between species of Drosophila. Conserved sites provide new understandings about E(spl) regulation during development. Conserved novel sequences found upstream of multiple E(spl) genes may play a role in the expression of these genes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.