ArticleGenetics2007
Molecular evolution of glutathione S-transferases in the genus Drosophila.
Article in Genetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
48 citing papers in PubMed, 111 citations in OpenAlex.
- Biochemical mechanisms of flonicamid resistance and its transgenerational effects in Bemisia tabaci mitotype Asia-II-1.Scientific reports · 2025Article
- Article
- Dispersal from the Qinghai-Tibet plateau by a high-altitude butterfly is associated with rapid expansion and reorganization of its genome.Nature communications · 2023Article
- Evolution of chemosensory and detoxification gene families across herbivorous Drosophilidae.G3 (Bethesda, Md.) · 2023Article
- Article
- De novo transcriptomes of six calanoid copepods (Crustacea): a resource for the discovery of novel genes.Scientific data · 2023Article
- Evolution of chemosensory and detoxification gene families across herbivorous Drosophilidae.bioRxiv : the preprint server for biology · 2023Article
- Chronic exposure to the star polycation (SPc) nanocarrier in the larval stage adversely impairs life history traits in Drosophila melanogaster.Journal of nanobiotechnology · 2022Article
- Article
- The transcription factor Xrp1 is required for PERK-mediated antioxidant gene induction ineLife · 2021Article
- Behavioral and Transcriptional Response to Selection for Olfactory Behavior inG3 (Bethesda, Md.) · 2020Article
- Molecular Evolution of the Glutathione S-Transferase Family in the Bemisia tabaci Species Complex.Genome biology and evolution · 2020Article
- Transcriptome analysis and comparison reveal divergence between the Mediterranean and the greenhouse whiteflies.PloS one · 2020Article
- Contraction of the ROS Scavenging Enzyme GlutathioneG3 (Bethesda, Md.) · 2019Article
- Complex evolution of the GSTM gene family involves sharing of GSTM1 deletion polymorphism in humans and chimpanzees.BMC genomics · 2018Article
- Rapid birth-death evolution and positive selection in detoxification-type glutathione S-transferases in mammals.PloS one · 2018Article
- Dual Roles of Glutathione in Ecdysone Biosynthesis and Antioxidant Function During Larval Development inGenetics · 2017Article
- Evolution of GSTD1 in Cactophilic Drosophila.Journal of molecular evolution · 2017Article
- The secret lives of Drosophila flies.eLife · 2015Review
- Characterization and expression profiling of glutathione S-transferases in the diamondback moth, Plutella xylostella (L.).BMC genomics · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
As classical phase II detoxification enzymes, glutathione S-transferases (GSTs) have been implicated in insecticide resistance and may have evolved in response to toxins in the niche-defining feeding substrates of Drosophila species. We have annotated the GST genes of the 12 Drosophila species with recently sequenced genomes and analyzed their molecular evolution. Gene copy number variation is attributable mainly to unequal crossing-over events in the large delta and epsilon clusters. Within these gene clusters there are also GST genes with slowly diverging orthologs. This implies that they have their own unique functions or have spatial/temporal expression patterns that impose significant selective constraints. Searches for positively selected sites within the GSTs identified G171K in GSTD1, a protein that has previously been shown to be capable of metabolizing the insecticide DDT. We find that the same radical substitution (G171K) in the substrate-binding domain has occurred at least three times in the Drosophila radiation. Homology-modeling places site 171 distant from the active site but adjacent to an alternative DDT-binding site. We propose that the parallel evolution observed at this site is an adaptive response to an environmental toxin and that sequencing of historical alleles suggests that this toxin was not a synthetic insecticide.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.