ArticleGenetics2007
Variable strength of translational selection among 12 Drosophila species.
Article in Genetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 42 citations in OpenAlex.
- Evidence for Non-optimal Codon Choice in Highly Transcribed Sex-Biased Genes of Drosophila melanogaster.Genome biology and evolution · 2026Article
- Comparative gene annotation and orthology assignments across 301 species of Drosophilidae.bioRxiv : the preprint server for biology · 2026Article
- Comparative gene annotation and orthology assignments across 301 species of Drosophilidae.PLoS biology · 2026Article
- Codon usage bias and dinucleotide preference in 29 Drosophila species.G3 (Bethesda, Md.) · 2021Article
- Phylogeny of the GenusGenetics · 2018Review
- Codon usage regulates protein structure and function by affecting translation elongation speed in Drosophila cells.Nucleic acids research · 2017Article
- Recent and Long-Term Selection Across Synonymous Sites in Drosophila ananassae.Journal of molecular evolution · 2016Article
- Codon usage affects the structure and function of the Drosophila circadian clock protein PERIOD.Genes & development · 2016Article
- Drosophila muller f elements maintain a distinct set of genomic properties over 40 million years of evolution.G3 (Bethesda, Md.) · 2015Article
- A nutrient-driven tRNA modification alters translational fidelity and genome-wide protein coding across an animal genus.PLoS biology · 2014Article
- Imogene: identification of motifs and cis-regulatory modules underlying gene co-regulation.Nucleic acids research · 2014Article
- Evidence for conserved post-transcriptional roles of unitary pseudogenes and for frequent bifunctionality of mRNAs.Genome biology · 2012Article
- Translational selection of genes coding for perfectly conserved proteins among three mosquito vectors.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2012Article
- Selection on codon usage and base composition in Drosophila americana.Biology letters · 2012Article
- Population genomic analysis of base composition evolution in Drosophila melanogaster.Genome biology and evolution · 2012Article
- Comparative analysis of codon usage bias and codon context patterns between dipteran and hymenopteran sequenced genomes.PloS one · 2012Article
- Determinants of translation efficiency and accuracy.Molecular systems biology · 2011Review
- Coadaptation of isoacceptor tRNA genes and codon usage bias for translation efficiency in Aedes aegypti and Anopheles gambiae.Insect molecular biology · 2011Article
- Evidence for a transport-trap mode of Drosophila melanogaster gurken mRNA localization.PloS one · 2010Article
- Recombination yet inefficient selection along the Drosophila melanogaster subgroup's fourth chromosome.Molecular biology and evolution · 2010Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Codon usage bias in Drosophila melanogaster genes has been attributed to negative selection of those codons whose cellular tRNA abundance restricts rates of mRNA translation. Previous studies, which involved limited numbers of genes, can now be compared against analyses of the entire gene complements of 12 Drosophila species whose genome sequences have become available. Using large numbers (6138) of orthologs represented in all 12 species, we establish that the codon preferences of more closely related species are better correlated. Differences between codon usage biases are attributed, in part, to changes in mutational biases. These biases are apparent from the strong correlation (r = 0.92, P < 0.001) among these genomes' intronic G + C contents and exonic G + C contents at degenerate third codon positions. To perform a cross-species comparison of selection on codon usage, while accounting for changes in mutational biases, we calibrated each genome in turn using the codon usage bias indices of highly expressed ribosomal protein genes. The strength of translational selection was predicted to have varied between species largely according to their phylogeny, with the D. melanogaster group species exhibiting the strongest degree of selection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.