ArticleGenetics2007
Conservation of epigenetic regulation, ORC binding and developmental timing of DNA replication origins in the genus Drosophila.
Article in Genetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 24 citations in OpenAlex.
- Finishing the egg.Genetics · 2024Article
- Anatomy and evolution of a DNA replication origin.Chromosoma · 2021Article
- Cryo-EM of dynamic protein complexes in eukaryotic DNA replication.Protein science : a publication of the Protein Society · 2017Review
- DNA sequence templates adjacent nucleosome and ORC sites at gene amplification origins in Drosophila.Nucleic acids research · 2015Article
- Induction of endocycles represses apoptosis independently of differentiation and predisposes cells to genome instability.Development (Cambridge, England) · 2014Article
- RNAP-II molecules participate in the anchoring of the ORC to rDNA replication origins.PloS one · 2013Article
- Emerging players in the initiation of eukaryotic DNA replication.Cell division · 2012Article
- Late replication domains in polytene and non-polytene cells of Drosophila melanogaster.PloS one · 2012Article
- Analysis of model replication origins in Drosophila reveals new aspects of the chromatin landscape and its relationship to origin activity and the prereplicative complex.Molecular biology of the cell · 2012Article
- The origin recognition complex: a biochemical and structural view.Sub-cellular biochemistry · 2012Review
- Preferential re-replication of Drosophila heterochromatin in the absence of geminin.PLoS genetics · 2010Article
- Heterochromatin protein 1 (HP1) modulates replication timing of the Drosophila genome.Genome research · 2010Article
- Common fragile sites are characterized by histone hypoacetylation.Human molecular genetics · 2009Article
- Intrinsically bent DNA sites in the Drosophila melanogaster third chromosome amplified domain.Molecular genetics and genomics : MGG · 2009Article
- Chromatin state marks cell-type- and gender-specific replication of the Drosophila genome.Genes & development · 2009Article
- The origin recognition complex protein family.Genome biology · 2009Review
- Beyond heterochromatin: SIR2 inhibits the initiation of DNA replication.Cell cycle (Georgetown, Tex.) · 2008Article
- Genome-wide studies highlight indirect links between human replication origins and gene regulation.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
There is much interest in how DNA replication origins are regulated so that the genome is completely duplicated each cell division cycle and in how the division of cells is spatially and temporally integrated with development. In the Drosophila melanogaster ovary, the cell cycle of somatic follicle cells is modified at precise times in oogenesis. Follicle cells first proliferate via a canonical mitotic division cycle and then enter an endocycle, resulting in their polyploidization. They subsequently enter a specialized amplification phase during which only a few, select origins repeatedly initiate DNA replication, resulting in gene copy number increases at several loci important for eggshell synthesis. Here we investigate the importance of these modified cell cycles for oogenesis by determining whether they have been conserved in evolution. We find that their developmental timing has been strictly conserved among Drosophila species that have been separate for approximately 40 million years of evolution and provide evidence that additional gene loci may be amplified in some species. Further, we find that the acetylation of nucleosomes and Orc2 protein binding at active amplification origins is conserved. Conservation of DNA subsequences within amplification origins from the 12 recently sequenced Drosophila species genomes implicates members of a Myb protein complex in recruiting acetylases to the origin. Our findings suggest that conserved developmental mechanisms integrate egg chamber morphogenesis with cell cycle modifications and the epigenetic regulation of origins.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.