ArticleMolecular and cellular biology2008
PTB/hnRNP I is required for RNP remodeling during RNA localization in Xenopus oocytes.
Article in Molecular and cellular biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 50 citations in OpenAlex.
- Clarion is a multi-label problem transformation method for identifying mRNA subcellular localizations.Briefings in bioinformatics · 2022Article
- Multivalent interactions with RNA drive recruitment and dynamics in biomolecular condensates iniScience · 2022Article
- Remnants of the Balbiani body are required for formation of RNA transport granules iniScience · 2022Article
- L-bodies are RNA-protein condensates driving RNA localization inMolecular biology of the cell · 2021Article
- The functional organization of axonal mRNA transport and translation.Nature reviews. Neuroscience · 2021Review
- Organizing the oocyte: RNA localization meets phase separation.Current topics in developmental biology · 2020Article
- Ciphers and Executioners: How 3'-Untranslated Regions Determine the Fate of Messenger RNAs.Frontiers in genetics · 2019Review
- Maternal messages to live by: a personal historical perspective.Genesis (New York, N.Y. : 2000) · 2017Review
- PTBP1 modulation of MCL1 expression regulates cellular apoptosis induced by antitubulin chemotherapeutics.Cell death and differentiation · 2016Article
- Hermes (Rbpms) is a Critical Component of RNP Complexes that Sequester Germline RNAs during Oogenesis.Journal of developmental biology · 2016Article
- Methods to study maternal regulation of germ cell specification in zebrafish.Methods in cell biology · 2016Article
- New insights into functional roles of the polypyrimidine tract-binding protein.International journal of molecular sciences · 2013Review
- RNA localization in Xenopus oocytes uses a core group of trans-acting factors irrespective of destination.RNA (New York, N.Y.) · 2013Article
- Article
- Control of cytoplasmic mRNA localization.Cellular and molecular life sciences : CMLS · 2012Review
- The nuclear experience of CPEB: implications for RNA processing and translational control.RNA (New York, N.Y.) · 2010Article
- Visualizing RNA localization in Xenopus oocytes.Journal of visualized experiments : JoVE · 2010Article
- Untranslated regions of a mobile transcript mediate RNA metabolism.Plant physiology · 2009Article
- Subcellular mRNA localization in animal cells and why it matters.Science (New York, N.Y.) · 2009Review
- hnRNP I is required to generate the Ca2+ signal that causes egg activation in zebrafish.Development (Cambridge, England) · 2009Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Transport of specific mRNAs to defined regions within the cell cytoplasm is a fundamental mechanism for regulating cell and developmental polarity. In the Xenopus oocyte, Vg1 RNA is transported to the vegetal cytoplasm, where localized expression of the encoded protein is critical for embryonic polarity. The Vg1 localization pathway is directed by interactions between key motifs within Vg1 RNA and protein factors recognizing those RNA sequences. We have investigated how RNA-protein interactions could be modulated to trigger distinct steps in the localization pathway and found that the Vg1 RNP is remodeled during cytoplasmic RNA transport. Our results implicate two RNA-binding proteins with key roles in Vg1 RNA localization, PTB/hnRNP I and Vg1RBP/vera, in this process. We show that PTB/hnRNP I is required for remodeling of the interaction between Vg1 RNA and Vg1RBP/vera. Critically, mutations that block this remodeling event also eliminate vegetal localization of the RNA, suggesting that RNP remodeling is required for localization.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.