ArticleRNA (New York, N.Y.)2008
Three essential and conserved regions of the group II intron are proximal to the 5'-splice site.
Article in RNA (New York, N.Y.), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Structures of a natural circularly permuted group II intron reveal mechanisms of branching and backsplicing.Nature structural & molecular biology · 2025Article
- Structural basis of circularly permuted group II intron self-splicing.Nature structural & molecular biology · 2025Article
- KnotAli: informed energy minimization through the use of evolutionary information.BMC bioinformatics · 2022Article
- Visualizing group II intron dynamics between the first and second steps of splicing.Nature communications · 2020Article
- Evidence for a group II intron-like catalytic triplex in the spliceosome.Nature structural & molecular biology · 2014Article
- Principles of ion recognition in RNA: insights from the group II intron structures.RNA (New York, N.Y.) · 2014Article
- Emerging views about the molecular structure of the spliceosomal catalytic center.RNA biology · 2012Article
- Article
- Crystal structure of a group II intron in the pre-catalytic state.Nature structural & molecular biology · 2012Article
- A conserved 3' extension in unusual group II introns is important for efficient second-step splicing.Nucleic acids research · 2009Article
- Structural insights into RNA splicing.Current opinion in structural biology · 2009Review
- A glimpse into the active site of a group II intron and maybe the spliceosome, too.RNA (New York, N.Y.) · 2008Article
- A conserved element that stabilizes the group II intron active site.RNA (New York, N.Y.) · 2008Article
- Crystal structure of a self-spliced group II intron.Science (New York, N.Y.) · 2008Article
- Article
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Authors and funding
2 authors.
Funding
Abstract
Despite the central role of group II introns in eukaryotic gene expression and their importance as biophysical and evolutionary model systems, group II intron tertiary structure is not well understood. In order to characterize the architectural organization of intron ai5gamma, we incorporated the photoreactive nucleotides s(4)U and s(6)dG at specific locations within the intron core and monitored the formation of cross-links in folded complexes. The resulting data reveal the locations for many of the most conserved, catalytically important regions of the intron (i.e., the J2/3 linker region, the IC1(i-ii) bulge in domain 1, the bulge of D5, and the 5'-splice site), showing that all of these elements are closely colocalized. In addition, we show by nucleotide analog interference mapping (NAIM) that a specific functional group in J2/3 plays a role in first-step catalysis, which is consistent with its apparent proximity to other first-step components. These results extend our understanding of active-site architecture during the first step of group II intron self-splicing and they provide a structural basis for spliceosomal comparison.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.