ArticleGenome biology2007
Comparative genomic analysis of the odorant-binding protein family in 12 Drosophila genomes: purifying selection and birth-and-death evolution.
Article in Genome biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 93 papers.
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93 citing papers in PubMed.
- Genome-wide identification of olfactory receptor and odorant-binding protein gene families and their roles in Heliothine chemosensory evolution.Insect molecular biology · 2026Article
- AgosOBP3 knockdown disrupts host plant preference in cotton-specialized Aphis gossypii.Pest management science · 2026Article
- Near chromosome-level genome assembly of Neomusotima conspurcatalis gives insights into the evolution of moth genome architecture and fern-insect interactions.G3 (Bethesda, Md.) · 2026Article
- Adaptive Evolution of Odorant-Binding and Chemosensory Protein Gene Families in GenusBiomolecules · 2026Article
- Genome-Wide Identification and Comparative Characterization of Chemosensory Gene Families in TwoInsects · 2026Article
- Genetic variation in olfactory pathways associated with host-seeking behavior in natural populations of Anopheles minimus, a primary malaria vector in western Thailand.Parasites & vectors · 2025Article
- From Macro to Micro: De Novo Genomes of Aedes Mosquitoes Enable Comparative Genomics Among Close and Distant Relatives.Genome biology and evolution · 2025Article
- Evolutionary Genomics of Gene Families: A Case Study of Insect Gustatory Receptors.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Variations in the expression of odorant binding and chemosensory proteins in the developmental stages of whitefly Bemisia tabaci Asia II-1.Scientific reports · 2024Article
- GALEON: a comprehensive bioinformatic tool to analyse and visualize gene clusters in complete genomes.Bioinformatics (Oxford, England) · 2024Article
- Article
- Identification and odor exposure regulation of odorant-binding proteins inFrontiers in physiology · 2024Article
- Identification of candidate chemosensory genes inFrontiers in physiology · 2024Article
- The seminal odorant binding protein Obp56g is required for mating plug formation and male fertility ineLife · 2023Article
- Evolution of fatty acid taste in drosophilids.Cell reports · 2023Article
- A supergene in seaweed flies modulates male traits and female perception.Proceedings. Biological sciences · 2023Article
- Evolution of five environmentally responsive gene families in a pine-feeding sawfly,Ecology and evolution · 2023Article
- Odorant-Binding Proteins and Chemosensory Proteins inInternational journal of molecular sciences · 2023Article
- Pleiotropic fitness effects of a Drosophila odorant-binding protein.G3 (Bethesda, Md.) · 2023Article
- A draft Diabrotica virgifera virgifera genome: insights into control and host plant adaption by a major maize pest insect.BMC genomics · 2023Article
33 more citing papers are in PubMed but not listed here.
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3 authors.
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Abstract
backgroundChemoreception is a widespread mechanism that is involved in critical biologic processes, including individual and social behavior. The insect peripheral olfactory system comprises three major multigene families: the olfactory receptor (Or), the gustatory receptor (Gr), and the odorant-binding protein (OBP) families. Members of the latter family establish the first contact with the odorants, and thus constitute the first step in the chemosensory transduction pathway.
resultsComparative analysis of the OBP family in 12 Drosophila genomes allowed the identification of 595 genes that encode putative functional and nonfunctional members in extant species, with 43 gene gains and 28 gene losses (15 deletions and 13 pseudogenization events). The evolution of this family shows tandem gene duplication events, progressive divergence in DNA and amino acid sequence, and prevalence of pseudogenization events in external branches of the phylogenetic tree. We observed that the OBP arrangement in clusters is maintained across the Drosophila species and that purifying selection governs the evolution of the family; nevertheless, OBP genes differ in their functional constraints levels. Finally, we detect that the OBP repertoire evolves more rapidly in the specialist lineages of the Drosophila melanogaster group (D. sechellia and D. erecta) than in their closest generalists.
conclusionOverall, the evolution of the OBP multigene family is consistent with the birth-and-death model. We also found that members of this family exhibit different functional constraints, which is indicative of some functional divergence, and that they might be involved in some of the specialization processes that occurred through the diversification of the Drosophila genus.
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