ArticleParasitology research2008
Goblet cells: are they an unspecific barrier against Giardia intestinalis or a gate?
Article in Parasitology research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 25 citations in OpenAlex.
- Article
- The Cysteine Protease Giardipain-1 fromInternational journal of molecular sciences · 2022Article
- Mucosal Defense AgainstFrontiers in immunology · 2022Review
- Assessment of the Nutritional Status, Diet and Intestinal Parasites in Hosted Saharawi Children.Children (Basel, Switzerland) · 2020Article
- Article
- CouldInfectious agents and cancer · 2018Article
- Goblet cells of the conjunctiva: A review of recent findings.Progress in retinal and eye research · 2016Review
- Immunopathological assessments of human Blastocystis spp. in experimentally infected immunocompetent and immunosuppresed mice.Parasitology research · 2016Article
- The invasive potential of Giardia intestinalis in an in vivo model.Scientific reports · 2015Article
- Review
- Article
- Expression of interferon gamma and proinflammatory cytokines in the cecal mucosa of rats experimentally infected with Blastocystis sp. strain RN94-9.Parasitology research · 2009Article
- Long-Term Follow-Up After Acute Gastroenteritis Caused by Giardia Infection in Juvenile Dogs.Journal of veterinary internal medicineArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Giardiosis is one of the major intestinal parasitic diseases of human beings as well as wild and domesticated animals. Several protective mechanisms against infection have been described. However, specific information about relationship between giardiosis and the increased proliferation of goblet cells (GC) in patients infected with Giardia intestinalis (Syn. G. duodenalis, G. lamblia) is scarce. In this work, we compare and quantify the number of GC, and have inferred their metabolic state in the small intestine of dogs parasitized with Giardia intestinalis compared to dogs without parasites. Small intestine segments were processed using routine methods for histology and electron microscopy; areas and cells were screened with an Axiovision Ver. 4.0 system. Data were analyzed by ANOVA and comparison of averages. Parasitized dogs showed higher GC numbers than nonparasitized ones. Averages were: 20+/-0.81 GC/25 microm(2) with independent mucin granules and 11+/-1.53 GC/25 microm(2) that were expelling mucus, compared to 11+/-0.94 GC/25 microm(2) and 1+/-0.27 GC/25 microm(2), respectively, in nonparasitized dogs (Tukey, p<0.001). The increases in GC number seem to be an unspecific defensive mechanism against Giardia trophozoites. However, we found some evidence supporting that GC hyperplasia could be a prejudicial to epithelial barrier that gives rise to gates allowing for Giardia-tissue invasion.
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