ReviewPsychopharmacology2008
Noradrenergic-glucocorticoid mechanisms in emotion-induced amnesia: from adaptation to disease.
Review in Psychopharmacology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 26 citations in OpenAlex.
- Noradrenergic enhancement of amygdala responses to fear.Social cognitive and affective neuroscience · 2009Trial
- Noradrenergic projections from the locus coeruleus to the amygdala constrain fear memory reconsolidation.eLife · 2020Article
- Emotional oddball: A review on memory effects.Psychonomic bulletin & review · 2019Review
- GANEing traction: The broad applicability of NE hotspots to diverse cognitive and arousal phenomena.The Behavioral and brain sciences · 2016Article
- Inferior frontal gyrus preserves working memory and emotional learning under conditions of impaired noradrenergic signaling.Frontiers in behavioral neuroscience · 2013Article
- Stress-induced cardiomyopathy and possible link to cerebral executive function: a case report.The primary care companion for CNS disorders · 2013Article
- Pharmacological treatment of PTSD - established and new approaches.Neuropharmacology · 2012Review
- Stress and glucocorticoids impair memory retrieval via β2-adrenergic, Gi/o-coupled suppression of cAMP signaling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Pharmacotherapy of PTSD: premises, principles, and priorities.Brain research · 2009Review
- The neurobiology of anxiety disorders: brain imaging, genetics, and psychoneuroendocrinology.The Psychiatric clinics of North America · 2009Review
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
discussionsThe interaction of emotion and episodic encoding has costs and benefits. These costs and benefits have been characterized in oddball experiments, where a violation of prevailing neutral context through aversive oddballs is associated with subsequent hypermnesia for the aversive oddball and peri-emotional amnesia for the neutral context. Both hypermnesia and peri-emotional amnesia are amygdala-dependent and vary as a function of noradrenergic-glucocorticoid input to the amygdala during emotional episodic encoding. Pharmacological enhancement of this input allows to model the maladaptive effects of emotion on episodic encoding. Extrapolation of these findings to conditions of emotional trauma suggests that disinhibited noradrenergic-glucocorticoid signaling could serve as a crucial etiological contributor to the pathogenesis of peri-traumatic amnesia (PTA) and post-traumatic stress disorder (PTSD).
conclusionsImmediate pharmacological blockade of noradrenergic-glucocorticoid signaling might prove effective in the secondary prevention of PTA and PTSD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.