ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2008
Vitamin D-binding protein gene microsatellite polymorphism influences BMD and risk of fractures in men.
Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- Understanding the characteristics of idiopathic osteoporosis by a systematic review and meta-analysis.Endocrine · 2023Pooled it
- Vitamin D Level Between Calcium-Phosphorus Homeostasis and Immune System: New Perspective in Osteoporosis.Current osteoporosis reports · 2024Review
- Insights and implications of sexual dimorphism in osteoporosis.Bone research · 2024Review
- An update of the effects of vitamins D and C in critical illness.Frontiers in medicine · 2022Review
- Differential proteome analysis in adolescent idiopathic scoliosis patients with thoracolumbar/lumbar curvatures.BMC musculoskeletal disorders · 2019Article
- Insights into the Role of Circadian Rhythms in Bone Metabolism: A Promising Intervention Target?BioMed research international · 2018Review
- Vitamin D metabolites in captivity? Should we measure free or total 25(OH)D to assess vitamin D status?The Journal of steroid biochemistry and molecular biology · 2017Review
- Vitamin Pharmacogenomics: New Insight into Individual Differences in Diseases and Drug Responses.Genomics, proteomics & bioinformatics · 2017Review
- Article
- Vitamin d binding protein and bone health.International journal of endocrinology · 2014Review
- Vitamin D-binding protein modifies the vitamin D-bone mineral density relationship.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2011Article
- Genetics of osteoporosis: accelerating pace in gene identification and validation.Human genetics · 2010Review
- Pharmacogenomics in osteoporosis: Steps toward personalized medicine.Pharmacogenomics and personalized medicine · 2009Article
- Common variants of the vitamin D binding protein gene and adverse health outcomes.Critical reviews in clinical laboratory sciencesReview
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelledHere we report the results of a vitamin D-binding protein gene microsatellite polymorphism study in 170 men, comprising healthy male subjects and men with osteoporosis-related symptomatic vertebral fractures. We confirm the results of an earlier study in a different cohort, showing relationship between certain genotypes of (TAAAn)-Alu repeats and reduced BMD and vertebral fractures.
introductionVitamin D-binding protein (DBP) plays a critical role in the transport and metabolism of metabolites of vitamin D, including the key calciotropic hormone 1alpha,25-dihydroxyvitamin D3 (1,25(OH)2D3).
methodsWe have investigated intra-intronic variable tandem (TAAA)n-Alu repeat expansion in the DBP gene in 170 men, comprising healthy male subjects and men with idiopathic osteoporosis and low trauma fractures. RESULTS AND
conclusionsThe predominant DBP-Alu genotype in the control subjects was 10/10 (frequency 0.421), whereas the frequency of this genotype in men with osteoporosis was 0.089. DBP-Alu alleles *10, *8 and *9, respectively, were the three commonest in both healthy subjects and men with osteoporosis. Allele *10 was associated with a lower risk of osteoporosis (OR 0.39, 95% CI 0.25-0.64; p < 0.0005), as was allele *11 (odds ratio 0.09, 95% CI 0.01-0.67; p < 0.007). Logistic regression gave similar results, showing that individuals with genotype 10/10 and 19-20 repeats (genotypes 9/10, 9/11, 10/10,) are protected from fracture or osteoporosis. Overall, there was a relationship between DBP Alu genotype and BMD, suggesting that DBP-Alu genotype may influence fracture risk. This effect may be mediated by changes in the circulating concentrations of DBP which influences free concentrations of vitamin D.
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